Adaptation of mesenteric collecting lymphatic pump function following acute alcohol intoxication.
Adaptation of mesenteric collecting lymphatic pump function following acute alcohol intoxication.
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DOI：
10.1111/j.1549-8719.2010.00050.x
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Breslin JW
中科院分区：
文献类型：
--
作者：
Souza-Smith FM;Kurtz KM;Molina PE;Breslin JW
急性酒精中毒通过未知机制增加肠淋巴液流量，可能影响粘膜免疫。我们检验了这样一个假设，即肠系膜淋巴管的内在泵功能增强有助于酒精中毒时肠淋巴流量增加。急性酒精中毒是由30%的酒精灌胃给清醒的，不受约束的大鼠通过腹腔植入导管。时间匹配的对照组接受无推注、溶媒或等热量葡萄糖。酒精给药后30分钟，将大鼠麻醉，分离肠系膜收集血管并插管以研究内在泵送参数。在单独的实验中，分离肠系膜动脉，以检查酒精对固有泵活性的直接影响。与葡萄糖组相比，酒精中毒动物的淋巴管收缩频率（CF）显著降低，与所有其他组相比，每搏输出量指数（SVI）升高，与假手术组相比，肌源性反应性降低。将压力从2 cm H2O升高到4 cm H2O，酒精组的体积流量指数增加了2.4倍，而假手术组增加了1.4倍。暴露于20 mM酒精的孤立性神经纤维化降低了肌源性张力，而CF或SVI没有变化。酒精中毒通过肠系膜集合淋巴管增强内在泵血。酒精直接降低淋巴肌张力，但对阶段性收缩的影响是通过一种未确定的机制发生的。
Acute alcohol intoxication increases intestinal lymph flow by unknown mechanisms, potentially impacting mucosal immunity. We tested the hypothesis that enhanced intrinsic pump function of mesenteric lymphatics contributes to increased intestinal lymph flow during alcohol intoxication. Acute alcohol intoxication was produced by intragastric administration of 30% alcohol to concious, unrestrained rats through surgically-implanted catheters. Time-matched controls received either no bolus, vehicle, or isocaloric dextrose. Thirty minutes after alcohol administration, rats were anesthetized and mesenteric collecting lymphatics were isolated and cannulated to study intrinsic pumping parameters. In separate experiments, mesenteric lymphatics were isolated to examine direct effects of alcohol on intrinsic pump activity. Lymphatics isolated from alcohol-intoxicated animals displayed slgnificantly decreased contraction frequency (CF) than the dextrose group, elevated stroke volume index (SVI) versus all other groups, and decreased myogenic responsiveness compared to sham. Elevating pressure from 2 to 4 cm H2O increased the volume flow index 2.4-fold in the alcohol group versus 1.4-fold for shams. Isolated lymphatics exposed to 20 mM alcohol had reduced myogenic tone, without changes in CF or SVI. Alcohol intoxication enhances intrinsic pumping by mesenteric collecting lymphatics. Alcohol directly decreases lymphatic myogenic tone, but effects on phasic contractions occur by an unidentified mechanism.
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影响因子：
3
作者：
ALTURA, BM;OGUNKOYA, A;ALTURA, BT
通讯作者：
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DOI：
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DOI：
10.1152/ajpheart.00763.2002
发表时间：
2003-06-01
影响因子：
4.8
作者：
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