The role of extracellular vesicles in Plasmodium and other protozoan parasites.

The role of extracellular vesicles in Plasmodium and other protozoan parasites.
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DOI:
10.1111/cmi.12259
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发表时间:
2014-03
影响因子:
3.4
通讯作者:
Marti M
Marti M
中科院分区:
生物学2区
文献类型:
--
作者:
Mantel PY;Marti M

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原生动物寄生虫和其他微生物利用各种途径在其种群内进行交流,并操纵其外部环境,其最终目标是平衡生长和传播速度。在包括人类在内的高等真核生物中,循环细胞外囊泡越来越被认为是生理和病理过程的关键介质。最近的证据表明,原生动物寄生虫,包括导致疟疾和南美锥虫病等主要人类疾病的寄生虫,也使用类似的机制。事实上,细胞内和细胞外的原生动物寄生虫分泌细胞外囊泡来促进生长和诱导传播,逃避宿主免疫系统,并操纵微环境。在这篇综述中,我们将讨论细胞外囊泡生物发生的一般途径及其在原虫感染中的作用。
Protozoan parasites and other microorganisms use various pathways to communicate within their own populations and to manipulate their outside environments, with the ultimate goal of balancing the rate of growth and transmission. In higher eukaryotes, including humans, circulating extracellular vesicles are increasingly recognized as key mediators of physiological and pathological processes. Recent evidence suggests that protozoan parasites, including those responsible for major human diseases such as malaria and Chagas disease, use similar machinery. Indeed, intracellular and extracellular protozoan parasites secrete extracellular vesicles to promote growth and induce transmission, to evade the host immune system, and to manipulate the microenvironment. In this review we will discuss the general pathways of extracellular vesicle biogenesis and their functions in protozoan infections.
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