Four-dimensional transcatheter intraarterial perfusion MR imaging for monitoring chemoembolization of hepatocellular carcinoma: preliminary results.
Four-dimensional transcatheter intraarterial perfusion MR imaging for monitoring chemoembolization of hepatocellular carcinoma: preliminary results.
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DOI：
10.1016/j.jvir.2008.08.010
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发表时间：
2008-11
影响因子：
2.9
通讯作者：
Omary, Reed A.
中科院分区：
文献类型：
--
作者：
Gaba, Ron C.;Wang, Dingxin;Lewandowski, Robert J.;Ryu, Robert K.;Sato, Kent T.;Kulik, Laura M.;Mulcahy, Mary F.;Larson, Andrew C.;Salem, Riad;Omary, Reed A.
肝细胞癌（HCC）经导管动脉化疗栓塞（TACE）的血管造影终点是主观的，最佳终点仍未知。经导管动脉内灌注磁共振成像（TRIP-MRI）在MR-介入放射学（MR-IR）组合套件中进行时，提供了一种量化手术中肿瘤灌注变化的客观方法，但以前仅限于两个空间维度。我们前瞻性地测试了一种新的随时间推移的容积采集（4D TRIP-MRI）可以测量TACE期间HCC灌注变化的假设。2007年2月至2007年12月期间，7名男性（平均年龄53岁，范围42-65岁）患有8个肿瘤（平均尺寸2.5×2.4 cm 2，直径范围1.5-5.2 cm），在MR-IR室接受了TACE，术中使用4D TRIP-MRI监测肿瘤灌注减少。微导管TACE采用1：1化疗：乳化造影剂混合物，然后是明胶微球。生成每个肿瘤的TACE前和TACE后时间-强度曲线。计算肿瘤灌注的半定量测量，包括曲线下面积（AUC）、峰值信号强度（SI）、达到峰值SI的时间和最大上升斜率（MUS），并使用配对t检验比较TACE前后的平均差异。4D TRIP-MRI监测的TACE在所有病例中均获得成功。计算的TACE前后AUC（439 vs 221，P=0.004，降低50%）、峰值SI（32 vs 19，P=0.012，降低41%）和MUS（11 vs 3，P=0.028，降低73%）在TACE后显示出统计学显着降低。达到SI峰值的时间没有显著变化（23秒与36秒，P=0.235，增加57%）。4D TRIP-MRI可以成功测量MR-IR监测TACE期间HCC灌注的半定量变化。未来的研究可能会将这些客观功能参数的变化与肿瘤缓解相关。
Angiographic endpoints for transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) are subjective, and optimal endpoints remain unknown. Transcatheter intraarterial perfusion magnetic resonance imaging (TRIP-MRI), when performed in a combined MR-interventional radiology (MR-IR) suite, offers an objective method to quantify intra-procedural tumor perfusion changes, but was previously limited to two spatial dimensions. We prospectively tested the hypothesis that a new volumetric acquisition over time, 4D TRIP-MRI, can measure HCC perfusion changes during TACE. Seven men (mean age 53 years, range 42-65 years) with eight tumors (mean size 2.5×2.4 cm2, diameter range 1.5-5.2 cm) underwent TACE in an MR-IR suite between 2/2007-12/2007, with intra-procedural tumor perfusion reductions monitored using 4D TRIP-MRI. Microcatheter TACE was performed using 1:1 chemotherapy:emulsifying contrast mixture followed by gelatin microspheres. Pre- and post-TACE time-intensity curves were generated for each tumor. Semi-quantitative measures of tumor perfusion, including area under curve (AUC), peak signal intensity (SI), time to peak SI, and maximum upslope (MUS), were calculated, and mean differences pre- and post-TACE were compared using paired t-tests. 4D TRIP-MRI monitored TACE was successful in all cases. Calculated pre- and post-TACE AUC (439 versus 221, P=0.004, 50% reduction), peak SI (32 versus 19, P=0.012, 41% reduction), and MUS (11 versus 3, P=0.028, 73% reduction) showed statistically significant reductions after TACE. Time to peak SI did not significantly change (23 versus 36 seconds, P=0.235, 57% increase). 4D TRIP-MRI can successfully measure semi-quantitative changes in HCC perfusion during MR-IR monitored TACE. Future studies may correlate changes in these objective functional parameters with tumor response.
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影响因子：
19.7
作者：
Larson, Andrew C.;Wang, Dingxin;Omary, Reed A.
通讯作者：
Omary, Reed A.
影响因子：
13.5
作者：
Lo, CM;Ngan, H;Wong, J
通讯作者：
Wong, J
DOI：
10.1097/01.rvi.0000182179.87340.d7
发表时间：
2005-11-01
影响因子：
2.9
作者：
Rhee, TK;Larson, AC;Omary, RA
通讯作者：
Omary, RA
影响因子：
19.7
作者：
Wang, Dingxin;Bangash, Affaan K.;Larson, Andrew C.
通讯作者：
Larson, Andrew C.
DOI：
10.1016/j.jvir.2007.07.008
发表时间：
2007-10-01
影响因子：
2.9
作者：
Virmani, Sumeet;Wang, Dingxin;Omary, Reed A.
通讯作者：
Omary, Reed A.