The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents.
The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents.
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DOI：
10.1186/1471-2148-14-109
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发表时间：
2014-05-19
影响因子：
3.4
通讯作者：
González AM
中科院分区：
文献类型：
--
作者：
Secher B;Fregel R;Larruga JM;Cabrera VM;Endicott P;Pestano JJ;González AM
全线粒体DNA （mtDNA）基因组分析极大地改善了人类mtDNA的系统发育和系统地理学。人类线粒体DNA单倍群U6被认为是旧石器时代现代人从西南亚返回北非的分子信号。利用230个完整序列对U6的系统发育进行了精化，并通过761个部分序列的分析完善了系统地理信息。这种方法为它到达非洲提供了时间上的限制，随后它根据气候波动在那里传播，以及它在史前和历史上第二次从非洲迁徙到欧洲、加那利群岛和美洲大陆。非洲内部U6的扩张和收缩真实地反映了该大陆发生的气候波动，这种波动也影响到加那利群岛。至少从新石器时代开始，地中海的接触就把这些血统带到了欧洲。反过来，欧洲殖民在整个美洲大陆带来了不同的U6血统，留下了殖民者起源的具体标志。
Complete mitochondrial DNA (mtDNA) genome analyses have greatly improved the phylogeny and phylogeography of human mtDNA. Human mitochondrial DNA haplogroup U6 has been considered as a molecular signal of a Paleolithic return to North Africa of modern humans from southwestern Asia. Using 230 complete sequences we have refined the U6 phylogeny, and improved the phylogeographic information by the analysis of 761 partial sequences. This approach provides chronological limits for its arrival to Africa, followed by its spreads there according to climatic fluctuations, and its secondary prehistoric and historic migrations out of Africa colonizing Europe, the Canary Islands and the American Continent. The U6 expansions and contractions inside Africa faithfully reflect the climatic fluctuations that occurred in this Continent affecting also the Canary Islands. Mediterranean contacts drove these lineages to Europe, at least since the Neolithic. In turn, the European colonization brought different U6 lineages throughout the American Continent leaving the specific sign of the colonizers origin.
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影响因子：
5.2
作者：
Fregel, Rosa;Pestano, Jose;Gonzalez, Ana M.
通讯作者：
Gonzalez, Ana M.
影响因子：
1.9
作者：
Coudray, C.;Olivieri, A.;Dugoujon, J. M.
通讯作者：
Dugoujon, J. M.
影响因子：
64.8
作者：
CANN, RL;STONEKING, M;WILSON, AC
通讯作者：
WILSON, AC
影响因子：
7.7
作者：
Excoffier, Laurent;Lischer, Heidi E. L.
通讯作者：
Lischer, Heidi E. L.
影响因子：
1.9
作者：
Fadhlaoui-Zid, K;Plaza, S;El gaaied, AB
通讯作者：
El gaaied, AB