Comprehensive analysis of the chromatin landscape in Drosophila melanogaster.
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster.
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DOI：
10.1038/nature09725
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发表时间：
2011-03-24
期刊：
影响因子：
64.8
通讯作者：
Park, Peter J.
中科院分区：
文献类型：
--
作者：
Kharchenko, Peter V.;Alekseyenko, Artyom A.;Schwartz, Yuri B.;Minoda, Aki;Riddle, Nicole C.;Ernst, Jason;Sabo, Peter J.;Larschan, Erica;Gorchakov, Andrey A.;Gu, Tingting;Linder-Basso, Daniela;Plachetka, Annette;Shanower, Gregory;Tolstorukov, Michael Y.;Luquette, Lovelace J.;Xi, Ruibin;Jung, Youngsook L.;Park, Richard W.;Bishop, Eric P.;Canfield, Theresa K.;Sandstrom, Richard;Thurman, Robert E.;MacAlpine, David M.;Stamatoyannopoulos, John A.;Kellis, Manolis;Elgin, Sarah C. R.;Kuroda, Mitzi I.;Pirrotta, Vincenzo;Karpen, Gary H.;Park, Peter J.
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which impact cell differentiation, gene regulation and other key cellular processes. We present a genome-wide chromatin landscape for Drosophila melanogaster based on 18 histone modifications, summarized by 9 prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNaseI hypersensitivity, GRO-seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements, and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions, and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.
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影响因子：
64.8
作者：
Heintzman, Nathaniel D.;Hon, Gary C.;Hawkins, R. David;Kheradpour, Pouya;Stark, Alexander;Harp, Lindsey F.;Ye, Zhen;Lee, Leonard K.;Stuart, Rhona K.;Ching, Christina W.;Ching, Keith A.;Antosiewicz-Bourget, Jessica E.;Liu, Hui;Zhang, Xinmin;Green, Roland D.;Lobanenkov, Victor V.;Stewart, Ron;Thomson, James A.;Crawford, Gregory E.;Kellis, Manolis;Ren, Bing
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Ren, Bing
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通讯作者：
Jenner RG
影响因子：
64.8
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通讯作者：
MacCallum, Iain
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Hoskins, Roger A.;Carlson, Joseph W.;Celniker, Susan E.
通讯作者：
Celniker, Susan E.
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通讯作者：
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