Peripartum women's perspectives on research study participation in the OneFlorida Clinical Research Consortium during COVID-19 pandemic.
Peripartum women's perspectives on research study participation in the OneFlorida Clinical Research Consortium during COVID-19 pandemic.
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果皮妇女对研究研究参与的研究观点，在Covid-19-19大流行期间。
DOI：
10.1017/cts.2022.476
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发表时间：
2023
影响因子：
2.6
通讯作者：
Lemas, Dominick J. J.
中科院分区：
文献类型：
--
作者：
Xu, Ke;Hsiao, Chu J. J.;Ballard, Hailey;Chachad, Nisha;Reeder, Callie F. F.;Shenkman, Elizabeth A. A.;Flood-Grady, Elizabeth;Louis-Jacques, Adetola F. F.;Smith, Erica L. L.;Thompson, Lindsay A. A.;Krieger, Janice;Francois, Magda;Lemas, Dominick J. J.
新冠肺炎疫情为人群层面的临床试验创造了前所未有的需求，这些试验的重点是发现挽救生命的疗法和治疗方法。然而，关于围产期人群对参与研究的看法的信息有限，围产期人群是大流行期间特别感兴趣的人群。符合条件的受访者年龄为18岁或以上，目前怀孕或有婴儿(≤12个月大)，居住在佛罗里达州，距离参与One佛罗里达临床研究联盟的地点不到50英里。受访者是在2020年4月至9月期间通过Qualtrics调查小组招募的。受访者完成了关于参与障碍和促进者的调查项目，并回答了社会人口学问题。在533名受访者中，大多数年龄在25岁至34岁之间(n=259，49%)，并被确认为白人(n=303，47%)和非西班牙裔(n=344，65%)。Facebook是受访者中最受欢迎的社交媒体平台。参与研究最常见的障碍包括对研究目标的解释不佳，对婴儿的不适，以及时间投入。通过医疗保健提供者招聘被认为是了解临床研究的最佳方式。在研究参与方面，“我自己”的影响最大，其次是家庭关系。非侵入性生物样本的可接受性很高。西班牙裔对参与随机研究的意愿有更高的积极看法(p=0.009)。受教育程度(p=0.007)对个人健康信息发布意愿有显著影响。当在孕期和产后期招募妇女进行围产期研究时，研究人员应该考虑说明常见障碍和首选研究信息来源的方案。基于社交媒体的招聘值得采用。
The COVID-19 pandemic created an unprecedented need for population-level clinical trials focused on the discovery of life-saving therapies and treatments. However, there is limited information on perception of research participation among perinatal populations, a population of particular interest during the pandemic. Eligible respondents were 18 years or older, were currently pregnant or had an infant (≤12 months old), and lived in Florida within 50 miles of sites participating in the OneFlorida Clinical Research Consortium. Respondents were recruited via Qualtrics panels between April and September 2020. Respondents completed survey items about barriers and facilitators to participation and answered sociodemographic questions. Of 533 respondents, most were between 25 and 34 years of age (n = 259, 49%) and identified as White (n = 303, 47%) and non-Hispanic (n = 344, 65%). Facebook was the most popular social media platform among our respondents. The most common barriers to research participation included poor explanation of study goals, discomforts to the infant, and time commitment. Recruitment through healthcare providers was perceived as the best way to learn about clinical research studies. When considering research participation, "myself" had the greatest influence, followed by familial ties. Noninvasive biological samples were highly acceptable. Hispanics had higher positive perspectives on willingness to participate in a randomized study (p = 0.009). Education (p = 0.007) had significant effects on willingness to release personal health information. When recruiting women during the pregnancy and postpartum periods for perinatal studies, investigators should consider protocols that account for common barriers and preferred study information sources. Social media-based recruitment is worthy of adoption.
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