Ex vivo MR volumetry of human brain hemispheres.
Ex vivo MR volumetry of human brain hemispheres.
复制标题
DOI：
10.1002/mrm.24661
复制
发表时间：
2014-01
影响因子：
3.3
通讯作者：
Arfanakis, Konstantinos
中科院分区：
文献类型：
--
作者：
Kotrotsou, Aikaterini;Bennett, David A.;Schneider, Julie A.;Dawe, Robert J.;Golak, Tom;Leurgans, Sue E.;Yu, Lei;Arfanakis, Konstantinos
这项工作的目的是：a）开发一种方法，用于人类大脑半球的离体MR体积测定，不污染组织病理学检查的结果，B）纵向评估区域脑体积死后，和c）调查MR体积测量之间的关系进行体内和体外。建立了一种离体人脑半球MR容积测量方法。对来自老年受试者的五个半球进行离体纵向成像。对所有数据集进行分段。评估离体测量的体积的纵向行为。对七名老年受试者进行了生前和死后成像，研究了体内和离体体积测量之间的关系。所提出的离体MR容量测定方法不会污染组织病理学检查的结果。在死后6个月的时间内，受试者内各时间点的体积变化远小于受试者间的体积变化。在体内和体外体积测量之间检测到密切的线性对应关系。用所提出的离体MR容积法测量的局部脑体积在死后6个月内保持相对不变。此外，体内和体外MR体积测量之间的线性关系表明，所提出的方法捕获的信息与生前的宏观结构的大脑特征。
The aims of this work were to: a) develop an approach for ex-vivo MR volumetry of human brain hemispheres that does not contaminate the results of histopathological examination, b) longitudinally assess regional brain volumes postmortem, and c) investigate the relationship between MR volumetric measurements performed in-vivo and ex-vivo. An approach for ex-vivo MR volumetry of human brain hemispheres was developed. Five hemispheres from elderly subjects were imaged ex-vivo longitudinally. All datasets were segmented. The longitudinal behavior of volumes measured ex-vivo was assessed. The relationship between in-vivo and ex-vivo volumetric measurements was investigated in seven elderly subjects imaged both ante-mortem and postmortem. The presented approach for ex-vivo MR volumetry did not contaminate the results of histopathological examination. For a period of 6 months postmortem, within-subject volume variation across time points was substantially smaller than inter-subject volume variation. A close linear correspondence was detected between in-vivo and ex-vivo volumetric measurements. Regional brain volumes measured with the presented approach for ex-vivo MR volumetry remain relatively unchanged for a period of 6 months postmortem. Furthermore, the linear relationship between in-vivo and ex-vivo MR volumetric measurements suggests that the presented approach captures information linked to ante-mortem macrostructural brain characteristics.
登录
查看更多内容
影响因子：
5.7
作者：
Jovicich J;Czanner S;Han X;Salat D;van der Kouwe A;Quinn B;Pacheco J;Albert M;Killiany R;Blacker D;Maguire P;Rosas D;Makris N;Gollub R;Dale A;Dickerson BC;Fischl B
通讯作者：
Fischl B
影响因子：
5.7
作者：
Dewey, Jeffrey;Hana, George;Russell, Troy;Price, Jared;McCaffrey, Daniel;Harezlak, Jaroslaw;Sem, Ekta;Anyanwu, Joy C.;Guttmann, Charles R.;Navia, Bradford;Cohen, Ronald;Tate, David F.
通讯作者：
Tate, David F.
影响因子：
3
作者：
Evers, P;Uylings, HBM
通讯作者：
Uylings, HBM
影响因子：
2.4
作者：
Bronge, L;Bogdanovic, N;Wahlund, LO
通讯作者：
Wahlund, LO
影响因子：
5.7
作者：
Gousias, Ioannis S.;Rueckert, Daniel;Hammers, Alexander
通讯作者：
Hammers, Alexander