Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy.
Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy.
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DOI：
10.1016/j.plefa.2014.10.008
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发表时间：
2015-03
影响因子：
3
通讯作者：
Carlson, S. E.
中科院分区：
文献类型：
--
作者：
Scholtz, S. A.;Kerling, E. H.;Shaddy, D. J.;Li, S.;Thodosoff, J. M.;Colombo, J.;Carlson, S. E.
一些FADS等位基因与较低的DHA和ARA状态相关，该状态通过血浆和红细胞（RBC）磷脂（PL）中花生四烯酸（ARA）和二十二碳六烯酸（DHA）的相对量来评估。我们在一组孕妇中确定了两种FADS单核苷酸多态性（SNP），并研究了每天补充600 mg DHA前后FADS 1 rs 174533和FADS 2 rs 174575与DHA和ARA状态的关系。研究中的205名孕妇被随机分配到安慰剂（混合大豆和玉米油）（n= 96）或600毫克海藻DHA（n=109），每天3粒胶囊，在怀孕的最后两个三个月。FADS 1 rs 174533（而非FADS 2 rs 174575）次要等位基因纯合子的女性基线时DHA和ARA状态较低。在分娩时，安慰剂组中FADS 1 rs 174533的次要等位基因纯合子与主要等位基因携带者相比具有较低的RBC-DHA（P = 0.031），而在DHA补充组中，所有基因型与基线相比具有较高的DHA状态（P = 0.001），并且状态不因基因型而异（P = 0.941）。令人惊讶的是，DHA而不是安慰剂降低了分娩时两种FADS SNP的次要等位基因纯合子的ARA状态，但不是主要等位基因纯合子。通过增加DHA摄入量来改变DHA与ARA比例的任何生理效应在一些FADS SNP的次要等位基因纯合子中似乎更大。
Some FADS alleles are associated with lower DHA and ARA status assessed by the relative amount of arachidonic acid (ARA) and docosahexaenoic acid (DHA) in plasma and red blood cell (RBC) phospholipids (PL). We determined two FADS single nucleotide polymorphisms (SNPs) in a cohort of pregnant women and examined the relationship of FADS1rs174533 and FADS2rs174575 to DHA and ARA status before and after supplementation with 600 mg per day of DHA. The 205 pregnant women studied were randomly assigned to placebo (mixed soy and corn oil) (n= 96) or 600 mg algal DHA (n=109) in 3 capsules per day for the last two trimesters of pregnancy. Women homozygous for the minor allele of FADS1rs174533 (but not FADS2rs174575) had lower DHA and ARA status at baseline. At delivery, minor allele homozygotes of FADS1rs174533 in the placebo group had lower RBC-DHA compared to major-allele carriers (P = 0.031), while in the DHA-supplemented group, all genotypes had higher DHA status compared to baseline (P = 0.001) and status did not differ by genotype (P = 0.941). Surprisingly, DHA but not the placebo decreased ARA status of minor allele homozygotes of both FADS SNPs but not major allele homozygotes at delivery. Any physiological effects of changing the DHA to ARA ratio by increasing DHA intake appears to be greater in minor allele homozygotes of some FADS SNPs.
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影响因子：
7.1
作者：
Carnielli, Virgilio P.;Simonato, Manuela;Cogo, Paola E.
通讯作者：
Cogo, Paola E.
影响因子：
7.1
作者：
Carlson, Susan E.;Colombo, John;Shaddy, D. Jill
通讯作者：
Shaddy, D. Jill
影响因子：
5.9
作者：
Cormier H;Rudkowska I;Paradis AM;Thifault E;Garneau V;Lemieux S;Couture P;Vohl MC
通讯作者：
Vohl MC
影响因子：
3.5
作者：
Steer, Colin D.;Hibbeln, Joseph R.;Smith, George Davey
通讯作者：
Smith, George Davey
影响因子：
6.5
作者：
ZAIL, SS;PICKERING, A
通讯作者：
PICKERING, A