Towards a systems-level understanding of development in the marine annelid Platynereis dumerilii.

Towards a systems-level understanding of development in the marine annelid Platynereis dumerilii.
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对海洋环节动物 Platynereis dumerilii 发育的系统级理解

DOI:
10.1016/j.gde.2016.07.005
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发表时间:
2016
影响因子:
4
通讯作者:
Jékely G
Jékely G
中科院分区:
生物学2区
文献类型:
--
作者:
Williams EA;Jékely G

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Platynereis umerilii是一种节段性海洋蠕虫,隶属于环节动物门,属于钩虫纲。扁虫很容易在实验室中维护,并通过螺旋裂解显示出高度刻板的发育,其幼虫小、透明、自由游泳,非常适合显微镜研究。一项在扁豆体内进行胚胎显微注射的方案使几种遗传工具得以开发,为功能研究铺平了道路。最近Platyneres的研究为几个信号通路在发育中的功能提供了洞察力。Platyneres也被证明是比较进化发育研究的有用模型系统,允许形成关于神经内分泌信号的进化、身体模式和器官发育的新假说。将现有的空间基因表达图谱、细胞谱系图谱和神经元回路的大数据集与发育基因的功能分析相结合,为未来旨在系统水平理解扁平苔藓发育的研究提供了一条很有前途的途径。
Platynereis dumeriliiis a segmented marine worm from the phylum Annelida, a member of the Lophotrochozoans.Platynereisis easily maintained in the lab and exhibits a highly stereotypic development through spiral cleavage with a small, transparent, free-swimming larva highly suitable for microscopy studies. A protocol for embryo microinjection inPlatynereishas enabled several genetic tools to be developed, paving the way for functional studies. RecentPlatynereisstudies have provided insights into the function of several signaling pathways in development.Platynereishas also proven a useful model system for comparative evolutionary developmental studies, allowing the formation of new hypotheses on the evolution of neuroendocrine signaling, body patterning, and organ development. Combining existing large datasets of spatial gene expression mapping, cell lineage mapping, and neuronal circuits with functional analyses of developmental genes represents a promising approach for future studies aiming at a systems-level understanding of development inPlatynereis.
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