Rewarding and incentive motivational effects of excitatory amino acid receptor antagonists into the median raphe and adjacent regions of the rat.
Rewarding and incentive motivational effects of excitatory amino acid receptor antagonists into the median raphe and adjacent regions of the rat.
复制标题
兴奋性氨基酸受体拮抗剂的奖励和激励动机作用进入大鼠的中间区域和相邻区域。
DOI：
10.1007/s00213-012-2759-0
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发表时间：
2012-12
影响因子：
3.4
通讯作者：
Ikemoto, Satoshi
中科院分区：
文献类型：
--
作者：
Webb, Sierra M.;Vollrath-Smith, Fiori R.;Shin, Rick;Jhou, Thomas C.;Xu, Shengping;Ikemoto, Satoshi
关键词：
调节对显著远端刺激的接近行为的动机过程（即激励动机）在自愿行为和动机障碍（如成瘾）中起着关键作用。这一过程可能由许多神经递质系统和许多脑结构网络介导，包括中缝区和中缝背区（分别为MR和DR）。我们试图通过颅内自我给药来检查MR和DR中兴奋性氨基酸受体的阻断是否有益，以及自我给药效果是否可以通过药物增强激励动机的有效性来解释，使用视觉感觉寻求程序。大鼠学会了将AMPA受体拮抗剂ZK 200775自我施用到MR， DR或内侧口桥脑网状区附近，但不施用于腹侧被盖区。NMDA受体拮抗剂AP5也可以自我给药到MR中，但它不容易自我给药到其他区域。当ZK 200775非偶然地进入MR时，大鼠明显增加了由短暂光刺激照明奖励的接近反应。此外，随机给药zk200775在MR中诱导了趋近反应的条件反射效应。大鼠自我给药兴奋性氨基酸受体拮抗剂进入MR和邻近区域。AMPA受体拮抗剂进入MR的自我给药效应可以在很大程度上解释为操纵的特性，以激活正在进行的接近行为和诱导条件接近。向中缝和邻近区域传入的谷氨酸能似乎在音调上抑制激励-动机过程。
The motivational process that regulates approach behavior toward salient distal stimuli (i.e., incentive motivation) plays a key role in voluntary behavior and motivational disorders such as addiction. This process may be mediated by many neurotransmitter systems and a network of many brain structures, including the median and dorsal raphe regions (MR and DR, respectively). We sought to examine whether the blockade of excitatory amino acid receptors in the MR and DR is rewarding, using intracranial self-administration, and whether the self-administration effect can be explained by drug’s effectiveness to enhance incentive motivation, using a visual sensation seeking procedure. Rats learned to self-administer the AMPA receptor antagonist ZK 200775 into the vicinity of the MR, DR, or medial oral pontine reticular regions, but not the ventral tegmental area. The NMDA receptor antagonist AP5 was also self-administered into the MR, while it was not readily self-administered into other regions. When ZK 200775 was noncontingently administered into the MR, rats markedly increased approach responses rewarded by brief illumination of a light stimulus. In addition, contingent administration of ZK 200775 into the MR induced a conditioning effect on approach responses. Rats self-administer excitatory amino acid receptor antagonists into the MR and adjacent regions. Self-administration effect of AMPA receptor antagonists into the MR can be largely explained by the manipulation’s properties to invigorate ongoing approach behavior and induces conditioned approach. Glutamatergic afferents to the median raphe and adjacent regions appear to tonically suppress incentive-motivational processes.
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影响因子：
8.2
作者：
Ikemoto, Satoshi
通讯作者：
Ikemoto, Satoshi
影响因子：
3
作者：
Ikemoto, S;Sharpe, LG
通讯作者：
Sharpe, LG
影响因子：
4.7
作者：
Ikemoto, S;Wise, RA
通讯作者：
Wise, RA
影响因子：
16.2
作者：
Jhou, Thomas C.;Fields, Howard L.;Baxter, Mark G.;Saper, Clifford B.;Holland, Peter C.
通讯作者：
Holland, Peter C.
影响因子：
5.4
作者：
BINDRA, D
通讯作者：
BINDRA, D