Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism.
Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism.
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自闭症患者丘脑感觉连接短暂增加和全脑活力下降
DOI：
10.1016/j.neuroimage.2018.06.003
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发表时间：
2019-04-15
期刊：
影响因子：
5.7
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
Fu Z;Tu Y;Di X;Du Y;Sui J;Biswal BB;Zhang Z;de Lacy N;Calhoun VD
自闭症谱系障碍（ASD）是一种神经发育障碍，与社会沟通缺陷和限制/重复行为相关，其特征是大规模的非典型皮质下-皮质连接，包括丘脑和感觉区域之间的静息状态功能连接受损。以往的研究通常集中在ASD的异常静态连接，而忽视了大脑连接中潜在的有价值的动态模式。然而，静息状态下的大脑连接确实是高度动态的，并且在精神疾病中已经广泛发现了动态大脑连接的异常。在这项研究中，我们调查了51个内在的连接网络之间的动态功能网络连接（dFNC）在170个个体与ASD和195个年龄匹配的典型发展（TD）控制使用独立成分分析和滑动窗口的方法。硬聚类状态分析和模糊元状态分析分别进行了探索的局部和全局异常的动态连接模式在ASD。我们研究了在每个功能状态下丘脑和感觉网络之间的dFNC的组差异和四个高维动态测量的组差异。结果表明，与TD对照组相比，ASD个体在某些功能状态下表现出下丘脑/下丘脑与某些感觉网络（右中央后回、双侧中央旁小叶和舌回）之间的瞬时连接增加，全脑功能网络的整体元状态动力学减弱。此外，这些非典型的动态模式显着相关的自闭症诊断观察时间表索引的自闭症症状。这些收敛的结果支持并扩展了先前关于ASD中丘脑和感觉区域之间的超连通性和稳定的全脑功能配置的观察。动态脑连接可能作为ASD的潜在生物标志物，对这些动态模式的进一步研究可能有助于我们进一步了解这种复杂的神经发育障碍的行为差异。
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with social communication deficits and restricted/repetitive behaviors and is characterized by large-scale atypical subcortical-cortical connectivity, including impaired resting-state functional connectivity between thalamic and sensory regions. Previous studies have typically focused on the abnormal static connectivity in ASD and overlooked potential valuable dynamic patterns in brain connectivity. However, resting-state brain connectivity is indeed highly dynamic, and abnormalities in dynamic brain connectivity have been widely identified in psychiatric disorders. In this study, we investigated the dynamic functional network connectivity (dFNC) between 51 intrinsic connectivity networks in 170 individuals with ASD and 195 age-matched typically developing (TD) controls using independent component analysis and a sliding window approach. A hard clustering state analysis and a fuzzy meta-state analysis were conducted respectively, for the exploration of local and global aberrant dynamic connectivity patterns in ASD. We examined the group difference in dFNC between thalamic and sensory networks in each functional state and group differences in four high-dimensional dynamic measures. The results showed that compared with TD controls, individuals with ASD show an increase in transient connectivity between hypothalamus/subthalamus and some sensory networks (right postcentral gyrus, bi paracentral lobule, and lingual gyrus) in certain functional states, and diminished global meta-state dynamics of the whole-brain functional network. In addition, these atypical dynamic patterns are significantly associated with autistic symptoms indexed by the Autism Diagnostic Observation Schedule. These converging results support and extend previous observations regarding hyperconnectivity between thalamic and sensory regions and stable whole-brain functional configuration in ASD. Dynamic brain connectivity may serve as a potential biomarker of ASD and further investigation of these dynamic patterns might help to advance our understanding of behavioral differences in this complex neurodevelopmental disorder.
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影响因子：
14.5
作者：
Bailey, A;Luthert, P;Lantos, P
通讯作者：
Lantos, P
聚类自闭症：在26个小鼠模型中使用神经解剖学差异来深入了解异质性。
影响因子：
11
作者：
Ellegood, J.;Anagnostou, E.;Babineau, B. A.;Crawley, J. N.;Lin, L.;Genestine, M.;DiCicco-Bloom, E.;Lai, J. K. Y.;Foster, J. A.;Penagarikano, O.;Geschwind, D. H.;Pacey, L. K.;Hampson, D. R.;Laliberte, C. L.;Mills, A. A.;Tam, E.;Osborne, L. R.;Kouser, M.;Espinosa-Becerra, F.;Xuan, Z.;Powell, C. M.;Raznahan, A.;Robins, D. M.;Nakai, N.;Nakatani, J.;Takumi, T.;van Eede, M. C.;Kerr, T. M.;Muller, C.;Blakely, R. D.;Veenstra-VanderWeele, J.;Henkelman, R. M.;Lerch, J. P.
通讯作者：
Lerch, J. P.
DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Di Martino A;Shehzad Z;Kelly C;Roy AK;Gee DG;Uddin LQ;Gotimer K;Klein DF;Castellanos FX;Milham MP
通讯作者：
Milham MP
DOI：
10.1098/rstb.2008.0331
发表时间：
2009-05-27
影响因子：
6.3
作者：
Casanova, Manuel F.;Trippe, Juan
通讯作者：
Trippe, Juan
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.