Modeling healthy male white matter and myelin development: 3 through 60months of age.
Modeling healthy male white matter and myelin development: 3 through 60months of age.
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DOI：
10.1016/j.neuroimage.2013.09.058
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发表时间：
2014-01-01
期刊：
影响因子：
5.7
通讯作者：
Deoni SC
中科院分区：
文献类型：
--
作者：
Dean DC 3rd;O'Muircheartaigh J;Dirks H;Waskiewicz N;Lehman K;Walker L;Han M;Deoni SC
在发育和行为障碍方面，一个新兴的假设是，它们是由混乱的大脑信息传递或连接减少引起的。鉴于髓鞘对有效的脑通信的重要性，婴儿期和儿童期髓鞘发育的表征可能提供与早期连接缺陷相关的显著信息。在这项工作中，我们调查区域和整个大脑的髓鞘水分数，定量磁共振成像测量灵敏度和特异性髓鞘含量的增长轨迹，从122个健康的男性儿童从3至60个月的年龄。我们检查常见的生长函数，以找到最具代表性的模型髓鞘成熟，并随后使用这些模型中最好的开发一个连续的人口平均，四维模型的正常髓鞘。通过与同一年龄段的63名男性儿童的独立样本进行比较，我们表明，所开发的模型是这个群体的代表。这项工作有助于了解健康婴儿和幼儿髓鞘形成的轨迹，进一步加深我们对早期大脑发育的了解，并提供了一个可能有助于识别发育异常的模型。提出了多种用于MWF轨迹建模的生长模型，对122名5岁以下男婴的MWF轨迹进行了建模，并采用贝叶斯信息准则对测试模型进行了统计学比较，建立了第一个儿童早期全脑髓鞘形成的四维模型，讨论了模型的实用性
An emerging hypothesis in developmental and behavioral disorders is that they arise from disorganized brain messaging or reduced connectivity. Given the importance of myelin to efficient brain communication, characterization of myelin development in infancy and childhood may provide salient information related to early connectivity deficits. In this work, we investigate regional and whole brain growth trajectories of the myelin water fraction, a quantitative magnetic resonance imaging measure sensitive and specific to myelin content, in data acquired from 122 healthy male children from 3 to 60 months of age. We examine common growth functions to find the most representative model of myelin maturation and subsequently use the best of these models to develop a continuous population-averaged, four-dimensional model of normative myelination. Through comparisons with an independent sample of 63 male children across the same age span, we show that the developed model is representative of this population. This work contributes to understanding the trajectory of myelination in healthy infants and toddlers, furthering our knowledge of early brain development, and provides a model that may be useful for identifying developmental abnormalities. Proposes various growth models for modeling MWF trajectories Demonstrates modeling of MWF trajectories of 122 male infants under 5 years Statistically compares tested models using Bayesian information criterion Generates first four-dimensional model of whole-brain myelination of early childhood Discusses the utility of developed model
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