Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair.
Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair.
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DOI：
10.3390/cells7100167
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发表时间：
2018-10-13
期刊：
影响因子：
6
通讯作者：
Valadi H
中科院分区：
文献类型：
--
作者：
Nawaz M;Shah N;Zanetti BR;Maugeri M;Silvestre RN;Fatima F;Neder L;Valadi H
细胞外囊泡（EV）是膜封闭的微米和纳米大小的囊泡，其从几乎每一个物种（从原核生物到真核生物）和从迄今为止研究的几乎每一种细胞类型分泌。EV含有生物活性分子的库，例如蛋白质（包括酶和转录因子）、脂质、碳水化合物和核酸，包括DNA、编码和非编码RNA。分泌的EV被邻近的细胞吸收，在那里它们将其内容物释放到受体细胞中，或者可以通过体液到达远处的器官。由于EV在细胞之间运输生物活性货物，它们已经成为局部微环境和器官间通讯中细胞外和细胞间活动的新型介质。在此，我们回顾了EV相关的基质重塑酶，如基质金属蛋白酶，乙酰肝素酶，透明质酸酶，聚集蛋白聚糖酶，及其调节剂，如细胞外基质金属蛋白酶诱导剂和金属蛋白酶的组织抑制剂的活动，作为在生理和病理条件下基质重塑的新手段。我们讨论了这些EV如何作为细胞外基质降解的新型介质，为各种病理条件（如癌症，心血管疾病，关节炎和代谢性疾病）准备一个允许的环境。此外，EV介导的基质重塑在组织修复中的作用及其作为器官治疗的潜在应用也已被综述。总的来说，这些知识可以有利于组织工程新方法的发展。
Extracellular vesicles (EVs) are membrane enclosed micro- and nano-sized vesicles that are secreted from almost every species, ranging from prokaryotes to eukaryotes, and from almost every cell type studied so far. EVs contain repertoire of bioactive molecules such as proteins (including enzymes and transcriptional factors), lipids, carbohydrates and nucleic acids including DNA, coding and non-coding RNAs. The secreted EVs are taken up by neighboring cells where they release their content in recipient cells, or can sail through body fluids to reach distant organs. Since EVs transport bioactive cargo between cells, they have emerged as novel mediators of extra- and intercellular activities in local microenvironment and inter-organ communications distantly. Herein, we review the activities of EV-associated matrix-remodeling enzymes such as matrix metalloproteinases, heparanases, hyaluronidases, aggrecanases, and their regulators such as extracellular matrix metalloproteinase inducers and tissue inhibitors of metalloproteinases as novel means of matrix remodeling in physiological and pathological conditions. We discuss how such EVs act as novel mediators of extracellular matrix degradation to prepare a permissive environment for various pathological conditions such as cancer, cardiovascular diseases, arthritis and metabolic diseases. Additionally, the roles of EV-mediated matrix remodeling in tissue repair and their potential applications as organ therapies have been reviewed. Collectively, this knowledge could benefit the development of new approaches for tissue engineering.
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DOI：
10.1016/j.matbio.2016.02.003
发表时间：
2016-05
期刊：
Matrix biology : journal of the International Society for Matrix Biology
影响因子：
--
作者：
Chaudhary SC;Kuzynski M;Bottini M;Beniash E;Dokland T;Mobley CG;Yadav MC;Poliard A;Kellermann O;Millán JL;Napierala D
通讯作者：
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DOI：
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发表时间：
2015-01
影响因子：
6.2
作者：
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影响因子：
16.6
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通讯作者：
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影响因子：
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通讯作者：
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