Movement-dependent electrical stimulation for volitional strengthening of cortical connections in behaving monkeys.
Movement-dependent electrical stimulation for volitional strengthening of cortical connections in behaving monkeys.
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DOI：
10.1073/pnas.2116321119
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发表时间：
2022-07-05
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
我们描述了一种电调节方案，在成年猴子的行为中，由自愿运动控制的刺激被用来加强参与这些运动的运动皮层神经元之间的联系。运动门控刺激创造了一种可塑性景观，即在刺激结束后很长一段时间内，门控条件刺激的重复运动以一种依赖于使用的方式增强了皮层连接，这一发现既独特又具有临床意义。在没有这种行为的情况下，几乎没有观察到连接强度的变化。同样，运动本身并不会产生连通性的变化。我们的数据强调了行为在可塑性中的关键作用，并为将运动门控刺激与使用依赖康复相结合，以加强因损伤或疾病而减弱的连接提供了强有力的支持。神经元的相关活动可以导致它们之间联系的长期加强或减弱。此外，由身体运动的执行或奖励的存在所赋予的行为环境可以调节由Hebbian机制引起的可塑性。在本研究中，我们将行为和诱导神经元关联结合起来，以加强成年行为猴子运动皮层的连接。相关活动是通过电调节方案来诱导的，在该方案中，由自主运动控制的刺激被用来产生与这些运动有关的运动皮质部位的神经元的协同激活。运动依赖性刺激的传递在条件反射后立即导致相关皮层连接强度的小幅增加。值得注意的是，当与进一步重复控制条件反射刺激的动作配对时，在没有额外条件反射刺激的情况下，以使用依赖的方式发生的皮质连接强度有了实质性的更大的增强。在没有这些运动的情况下，运动-皮层连接的强度几乎没有变化。在没有条件作用的情况下，运动行为的表现也没有产生任何连接的变化。我们的研究结果表明，将运动门控刺激与刺激结束后进一步自然使用“条件”通路相结合，可以在成年灵长类动物中产生使用依赖性的连接强化，突出了行为在皮层可塑性中的重要作用。我们的数据还为将运动门控刺激与使用依赖的物理康复相结合，以加强因中风或脊髓损伤而减弱的连接提供了强有力的支持。
We describe an electrical-conditioning protocol in adult behaving monkeys in which stimuli gated by voluntary movements were used to strengthen connections between motor-cortical neurons involved in those movements. Movement-gated stimulation created a plastic landscape in which repetition of the movements that gated conditioning stimuli produced strengthening of cortical connections, in a use-dependent manner, long after stimulation had ended, a finding that is both unique and clinically relevant. In the absence of such behavior, little change was observed in the strength of connections. Similarly, movements alone did not produce changes in connectivity. Our data highlight a critical role for behavior in plasticity and provide strong support for combining movement-gated stimulation with use-dependent rehabilitation for strengthening connections weakened by injury or disease. Correlated activity of neurons can lead to long-term strengthening or weakening of the connections between them. In addition, the behavioral context, imparted by execution of physical movements or the presence of a reward, can modulate the plasticity induced by Hebbian mechanisms. In the present study, we have combined behavior and induced neuronal correlations to strengthen connections in the motor cortex of adult behaving monkeys. Correlated activity was induced using an electrical-conditioning protocol in which stimuli gated by voluntary movements were used to produce coactivation of neurons at motor-cortical sites involved in those movements. Delivery of movement-dependent stimulation resulted in small increases in the strength of associated cortical connections immediately after conditioning. Remarkably, when paired with further repetition of the movements that gated the conditioning stimuli, there were substantially larger gains in the strength of cortical connections, which occurred in a use-dependent manner, without delivery of additional conditioning stimulation. In the absence of such movements, little change was observed in the strength of motor-cortical connections. Performance of the motor behavior in the absence of conditioning also did not produce any changes in connectivity. Our results show that combining movement-gated stimulation with further natural use of the “conditioned” pathways after stimulation ends can produce use-dependent strengthening of connections in adult primates, highlighting an important role for behavior in cortical plasticity. Our data also provide strong support for combining movement-gated stimulation with use-dependent physical rehabilitation for strengthening connections weakened by a stroke or spinal cord injury.
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影响因子：
9.2
作者：
Bunday, Karen L.;Perez, Monica A.
通讯作者：
Perez, Monica A.
影响因子：
56.9
作者：
AHISSAR, E;VAADIA, E;ABELES, M
通讯作者：
ABELES, M
影响因子：
7.7
作者：
Bunday, Karen L.;Urbin, M. A.;Perez, Monica A.
通讯作者：
Perez, Monica A.
影响因子：
2.5
作者：
FETZ, EE;CHENEY, PD
通讯作者：
CHENEY, PD
DOI：
10.1126/science.aaa8035
发表时间：
2015-11-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Griffin DM;Hoffman DS;Strick PL
通讯作者：
Strick PL