Helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis.
Helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis.
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DOI：
10.3346/jkms.2007.22.1.63
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发表时间：
2007-02
影响因子：
4.5
通讯作者：
Kim KM
中科院分区：
文献类型：
--
作者：
Joo M;Kwak JE;Chang SH;Kim H;Chi JG;Kim KA;Yang JH;Lee JS;Moon YS;Kim KM
本研究的目的是评估海尔曼螺杆菌相关性胃炎的临床病理特征，并比较海尔曼螺杆菌相关性胃炎与幽门螺杆菌相关性胃炎。我们回顾了 5,985 份连续胃活检标本。所有幽门螺杆菌感染慢性胃炎病例均采用更新悉尼系统进行评估，并比较海尔曼氏菌相关性胃炎和幽门螺杆菌相关性胃炎组之间所有胃炎变量的等级。海尔曼螺杆菌相关性胃炎10例（0.17%），幽门螺杆菌相关性胃炎3285例（54.9%）。该生物体表面位于粘膜层内，不粘附于上皮细胞。有趣的是，在一种情况下，在细胞损伤的壁细胞中观察到许多胞浆内海尔曼螺杆菌生物体。检测到一例伴有海尔曼螺杆菌感染的低度粘膜相关淋巴组织（MALT）淋巴瘤病例。与幽门螺杆菌相关性胃炎相比，海尔曼螺杆菌相关性胃炎表现出较不严重的中性粒细胞活性（p<0.0001）、单核细胞浸润（p=0.0029）以及无糜烂或溃疡的慢性胃炎内镜检查结果（p=0.0309）。总之，我们提出了海尔曼螺杆菌相关性胃炎与幽门螺杆菌相关性胃炎相比的详细临床病理学结果。海尔曼螺杆菌相关性胃炎并不常见，而且比幽门螺杆菌相关性胃炎轻，但它对于 MALT 淋巴瘤的发展可能值得注意。
The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis. We reviewed 5,985 consecutive gastric biopsy specimens. All cases of chronic gastritis with Helicobacter infection were evaluated with the Updated Sydney System, and the grades of all gastritis variables were compared between H. heilmannii-associated gastritis and H. pylori-associated gastritis groups. There were 10 cases of H. heilmannii-associated gastritis (0.17%) and 3,285 cases of H. pylori-associated gastritis (54.9%). The organisms were superficially located within the mucous layer without adhesion to epithelial cells. Interestingly, in one case many intracytoplasmic H. heilmannii organisms were observed in parietal cells with cell damage. A case of low-grade mucosa-associated lymphoid tissue (MALT) lymphoma concomitant with H. heilmannii infection was detected. Compared to H. pylori-associated gastritis, H. heilmannii-associated gastritis showed less severe neutrophilic activity (p<0.0001), mononuclear cell infiltration (p=0.0029), and endoscopic findings of chronic gastritis devoid of erosion or ulcer (p=0.0309). In conclusion, we present the detailed clinicopathologic findings of H. heilmannii-associated gastritis compared to H. pylori-associated gastritis. H. heilmannii-associated gastritis is uncommon and milder than H. pylori-associated gastritis, however it may be noteworthy with respect to the development of MALT lymphoma.
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影响因子：
3.1
作者：
DYE, KR;MARSHALL, BJ;MCCALLUM, RW
通讯作者：
MCCALLUM, RW
影响因子：
3.4
作者：
Ierardi, E;Monno, RA;Francavilla, A
通讯作者：
Francavilla, A
影响因子：
29.4
作者：
Morgner, A;Lehn, N;Bayerdörffer, E
通讯作者：
Bayerdörffer, E
影响因子：
7.3
作者：
O'Rourke, JL;Dixon, MF;Lee, A
通讯作者：
Lee, A
影响因子：
1.9
作者：
Stolte, M;Kroher, G;Bethke, B
通讯作者：
Bethke, B