Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk.
Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk.
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DOI：
10.1016/j.numecd.2015.01.007
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Mantzoros CS
中科院分区：
文献类型：
--
作者：
Farr OM;Ko BJ;Joung KE;Zaichenko L;Usher N;Tsoukas M;Thakkar B;Davis CR;Crowell JA;Mantzoros CS
有一些证据表明，创伤后应激障碍（PTSD）和早期生活逆境可能会影响代谢结果，如肥胖，糖尿病和心血管疾病。然而，这些因素是否以及如何相互作用尚不清楚。我们分析了一项横断面和纵向研究的数据，以确定创伤后应激障碍的严重程度如何影响肥胖、胰岛素敏感性以及心血管风险的关键指标和生物标志物。然后，我们研究了创伤后应激障碍和早期生活逆境如何相互作用以影响这些相同的结果。PTSD严重程度与肥胖、糖尿病和心血管疾病的风险增加相关，症状越严重，BMI、瘦素、纤维蛋白原和血压值越高，胰岛素敏感性值越低。创伤后应激障碍和早期生活逆境对这些代谢结果有累加效应。纵向研究证实了横断面研究的结果，并显示在2.5年的随访期间，脂肪量，瘦素，CRP，ICAM和TNFRII显着增加，PTSD的严重程度更高。患有早期生活逆境和创伤后应激障碍的个体处于高风险状态，应仔细监测肥胖，胰岛素抵抗和心脏代谢风险。
There is some evidence that posttraumatic stress disorder (PTSD) and early life adversity may influence metabolic outcomes such as obesity, diabetes, and cardiovascular disease. However, whether and how these interact is not clear. We analyzed data from a cross-sectional and a longitudinal study to determine how PTSD severity influences obesity, insulin sensitivity, and key measures and biomarkers of cardiovascular risk. We then looked at how PTSD and early life adversity may interact to impact these same outcomes. PTSD severity is associated with increasing risk of obesity, diabetes, and cardiovascular disease, with higher symptoms correlating with higher values of BMI, leptin, fibrinogen, and blood pressure, and lower values of insulin sensitivity. PTSD and early life adversity have an additive effect on these metabolic outcomes. The longitudinal study confirmed findings from the cross sectional study and showed that fat mass, leptin, CRP, ICAM, and TNFRII were significantly increased with higher PTSD severity during a 2.5 year follow-up period. Individuals with early life adversity and PTSD are at high risk and should be monitored carefully for obesity, insulin resistance, and cardiometabolic risk.
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