Hippocampal ripples signal contextually mediated episodic recall.
Hippocampal ripples signal contextually mediated episodic recall.
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DOI：
10.1073/pnas.2201657119
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发表时间：
2022-10-04
影响因子：
11.1
通讯作者：
Kahana, Michael J.
中科院分区：
文献类型：
--
作者：
Sakon, John J.;Kahana, Michael J.
内侧颞叶（MTL）的高频电生理事件--被称为波纹--与记忆提取有关。在这里，使用神经外科患者执行自由回忆任务的电生理记录，我们证实，海马波纹上升率之前，在人类的单词回忆。值得注意的是，我们看到最高的涟漪率之前，回忆最有可能通过上下文恢复实现，支持啮齿动物的工作，涟漪反映参与情景记忆机制的假设。我们还发现，海马区角氨区1和齿状回比附近的MTL皮层区域的回忆前显着更多的波纹，揭示了成功检索情节记忆的生理相关性。高频振荡事件，称为波纹，代表大脑中神经活动的同步性。最近的证据表明，内侧颞叶（MTL）波纹支持记忆提取。然而，目前还不清楚涟漪是否标志着情景记忆的恢复。分析245名神经外科参与者执行情景回忆任务的电生理MTL记录，我们发现海马涟漪的速率上升之前，最近形成的记忆的自由回忆。这种回忆前涟漪效应（PRE）在海马的CA 1和CA 3/齿状回（CA 3/DG）子区域比邻近的MTL区域内嗅和海马旁皮质更强。PRE也是较强的检索前的时间和语义集群，与非集群，回忆，表明参与的涟漪在上下文中的恢复，这是一个标志性的情景记忆。
High-frequency electrophysiological events in the medial temporal lobe (MTL)—known as ripples—have been linked to memory retrieval. Here, using electrophysiological recordings from neurosurgical patients performing free-recall tasks, we confirm that hippocampal ripples rise in rate just prior to word recall in humans. Notably, we see the highest ripple rates prior to recalls most likely achieved via contextual reinstatement, supporting hypotheses from rodent work that ripples reflect engagement of episodic memory mechanisms. We also find significantly more ripples prior to recall in hippocampal areas cornu ammonis region 1 and dentate gyrus than in nearby MTL cortical regions, uncovering a physiological correlate of successfully retrieved episodic memories. High-frequency oscillatory events, termed ripples, represent synchrony of neural activity in the brain. Recent evidence suggests that medial temporal lobe (MTL) ripples support memory retrieval. However, it is unclear if ripples signal the reinstatement of episodic memories. Analyzing electrophysiological MTL recordings from 245 neurosurgical participants performing episodic recall tasks, we find that the rate of hippocampal ripples rises just prior to the free recall of recently formed memories. This prerecall ripple effect (PRE) is stronger in the CA1 and CA3/dentate gyrus (CA3/DG) subfields of the hippocampus than the neighboring MTL regions entorhinal and parahippocampal cortex. PRE is also stronger prior to the retrieval of temporally and semantically clustered, as compared with unclustered, recalls, indicating the involvement of ripples in contextual reinstatement, which is a hallmark of episodic memory.
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