Serum Bisphenol A, glucose homeostasis, and gestational diabetes mellitus in Chinese pregnant women: a prospective study
Serum Bisphenol A, glucose homeostasis, and gestational diabetes mellitus in Chinese pregnant women: a prospective study
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中国孕妇血清双酚 A、葡萄糖稳态和妊娠期糖尿病：一项前瞻性研究
DOI：
10.1007/s11356-020-11263-4
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发表时间：
2020-10
影响因子：
5.8
通讯作者：
Gengsheng He
中科院分区：
文献类型：
--
作者：
Jiaqi Yang;Hexing Wang;Hongyi Du;Linji Xu;Shuping Liu;Jianping Yi;Yue Chen;Qingwu Jiang;Gengsheng He
实验室研究表明，暴露于双酚A(BPA)可能会扰乱血糖稳态，但流行病学研究有限，对孕妇的结果不一致。为此，孕妇是从2013年至2014年在中国北部唐山市建立的孕妇队列中挑选出来的。在妊娠早期测定血清双酚A浓度，在妊娠早期、中期和晚期分别重复测定空腹血糖和胰岛素水平。对妊娠期糖尿病(GDM)患者在妊娠中晚期进行口服葡萄糖耐量试验(OGTT)检查。自然对数转化双酚A(LnBPA)与孕中期空腹血糖水平(β(95%CI)：0.038(0.015~0.061))、空腹胰岛素水平(0.195(0.069~0.321))、稳态模型胰岛素抵抗指数(HOMA-IR)(0.226(0.087~0.364))呈正相关。将血清BPA水平分为低、中、高三组后，孕中期BPA与血糖、胰岛素、HOMA-IR呈剂量-反应关系。BPA浓度升高有增加妊娠期糖尿病风险的趋势，但无统计学意义(BPA浓度高低的风险比：2.51(95%CI：0.68~9.30))。这些发现表明，暴露于双酚A可能会影响血糖稳态，怀孕中期可能是一个潜在的敏感期。
Lab studies have suggested that exposure to Bisphenol A (BPA) could disturb glucose homeostasis, but epidemiologic studies are limited and show inconsistent results for pregnant women. For this, 535 pregnant women were selected from a pregnant women cohort established in Tangshan City in North China between 2013 and 2014. Serum concentrations of BPA were measured in the early term of pregnancy, and fasting glucose and insulin levels were repeatedly measured in each of three terms of pregnancy (early, middle, and late). Gestational diabetes mellitus (GDM) were examined by Oral Glucose Tolerance Test (OGTT) in the middle and late terms of pregnancy. BPA was detected in 97.5% of pregnant women with a median of 6.50 ng/ml. Natural log-transformed BPA (Ln BPA) was positively associated with fasting glucose level (β (95% CI): 0.038 (0.015~0.061)), fasting insulin level (0.195 (0.069~0.321)), and homeostasis model insulin resistance index (HOMA-IR) (0.226 (0.087~0.364)) in the middle term of pregnancy by multiple linear regression model after adjusting for potential confounders. After serum BPA levels were divided into three groups (low, middle, and high), BPA showed a positive dose-response relationship with blood glucose, insulin, and HOMA-IR in the middle term of pregnancy. Increased BPA concentration tended to increase the RR of GDM although not statistically significant (risk ratio: 2.51 (95% CI: 0.68~9.30) for high vs low tertile of BPA concentrations). These findings suggested that exposure to BPA might affect glucose homeostasis and the middle term of pregnancy was a potentially sensitive period.
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影响因子：
4.8
作者：
A. Zsarnovszky;Hoa H. Le;Hong-Sheng Wang;S. Belcher
通讯作者：
A. Zsarnovszky;Hoa H. Le;Hong-Sheng Wang;S. Belcher
影响因子：
6.1
作者：
Silva-Zolezzi I;Samuel TM;Spieldenner J
通讯作者：
Spieldenner J
影响因子：
4.2
作者：
Zhu Y;Zhang C
通讯作者：
Zhang C
影响因子：
2.7
作者：
Gayoso-Diz P;Otero-González A;Rodriguez-Alvarez MX;Gude F;García F;De Francisco A;Quintela AG
通讯作者：
Quintela AG
影响因子：
3.2
作者：
Gao C;Sun X;Lu L;Liu F;Yuan J
通讯作者：
Yuan J