Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth.
Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth.
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DOI：
10.1016/j.dcn.2023.101257
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发表时间：
2023-06
影响因子：
4.7
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Killanin, Abraham D.;Taylor, Brittany K.;Embury, Christine M.;Picci, Giorgia;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Heinrichs-Graham, Elizabeth;Wilson, Tony W.
近期的研究通过考察与运动相关的振荡反应的发展，来描绘从儿童期到青年期的成熟变化。虽然这些研究包含了青春期过渡阶段的青少年，但没有研究探究睾酮水平对运动皮层动力学和表现的影响。我们收集了58名9 - 15岁青少年的唾液睾酮样本，并在一项复杂的运动排序任务中记录了脑磁图。使用多重中介模型检验了睾酮、年龄、任务行为和贝塔（15 - 23Hz）振荡动力学之间的关系。我们发现睾酮介导了年龄对运动相关贝塔活动的影响。我们还发现年龄对运动持续时间的影响是由睾酮和反应时间介导的。有趣的是，睾酮与运动表现之间的关系并不是由左侧初级运动皮层的贝塔活动介导的，这可能表明高阶运动区域的重要性。总体而言，我们的研究结果表明，睾酮与复杂运动表现的神经和行为指标存在独特的关联，这超出了文献中已有的描述。这些发现首次将睾酮水平的发育变化与服务于复杂运动规划和执行的贝塔振荡动力学的成熟以及运动表现的特定指标联系起来。
Recent investigations have studied the development of motor-related oscillatory responses to delineate maturational changes from childhood to young adulthood. While these studies included youth during the pubertal transition period, none have probed the impact of testosterone levels on motor cortical dynamics and performance. We collected salivary testosterone samples and recorded magnetoencephalography during a complex motor sequencing task in 58 youth aged 9–15 years old. The relationships between testosterone, age, task behavior, and beta (15–23 Hz) oscillatory dynamics were examined using multiple mediation modeling. We found that testosterone mediated the effect of age on movement-related beta activity. We also found that the effect of age on movement duration was mediated by testosterone and reaction time. Interestingly, the relationships between testosterone and motor performance were not mediated by beta activity in the left primary motor cortex, which may indicate the importance of higher-order motor regions. Overall, our results suggest that testosterone has unique associations with neural and behavioral indices of complex motor performance, beyond those already characterized in the literature. These findings are the first to link developmental changes in testosterone levels to maturation of beta oscillatory dynamics serving complex motor planning and execution, and specific measures of motor performance.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
运动后β振荡在运动终止中的功能作用。
影响因子：
3.1
作者：
Heinrichs-Graham E;Kurz MJ;Gehringer JE;Wilson TW
通讯作者：
Wilson TW
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
3.7
作者：
Bramen JE;Hranilovich JA;Dahl RE;Chen J;Rosso C;Forbes EE;Dinov ID;Worthman CM;Sowell ER
通讯作者：
Sowell ER
影响因子：
5.7
作者：
Fung, Madison H.;Heinrichs-Graham, Elizabeth;Taylor, Brittany K.;Frenzel, Michaela R.;Eastman, Jacob A.;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Wilson, Tony W.
通讯作者：
Wilson, Tony W.