Dishevelled links basal body docking and orientation in ciliated epithelial cells.
Dishevelled links basal body docking and orientation in ciliated epithelial cells.
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DOI:
10.1016/j.tcb.2008.08.004
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发表时间:
2008-11
影响因子:
19
通讯作者:
Axelrod, Jeffrey D.
中科院分区:
文献类型:
--
作者:
Vladar, Eszter K.;Axelrod, Jeffrey D.
Some epithelia contain cells with multiple, motile cilia that beat in a concerted fashion. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and of the coordinated planar polarization of cilia that leads to their concerted motility. Recent, elegant work by Park and colleagues, using embryonic frog epidermis, demonstrates that Dishevelled (Dvl), a key regulator of both the Wnt/β-catenin and Planar Cell Polarity (PCP) pathways, controls both the docking and planar polarization of ciliary basal bodies.
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