A genome-wide association meta-analysis identifies new childhood obesity loci.
A genome-wide association meta-analysis identifies new childhood obesity loci.
复制标题
DOI：
10.1038/ng.2247
复制
发表时间：
2012-05
期刊：
影响因子：
30.8
通讯作者：
Grant, Struan F. A.
中科院分区：
文献类型：
--
作者：
Bradfield, Jonathan P.;Taal, H. Rob;Timpson, Nicholas J.;Scherag, Andre;Lecoeur, Cecile;Warrington, Nicole M.;Hypponen, Elina;Holst, Claus;Valcarcel, Beatriz;Thiering, Elisabeth;Salem, Rany M.;Schumacher, Fredrick R.;Cousminer, Diana L.;Sleiman, Patrick M. A.;Zhao, Jianhua;Berkowitz, Robert I.;Vimaleswaran, Karani S.;Jarick, Ivonne;Pennell, Craig E.;Evans, David M.;St Pourcain, Beate;Berry, Diane J.;Mook-Kanamori, Dennis O.;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, Andre G.;van Duijn, Cornelia M.;van der Valk, Ralf J. P.;de Jongste, Johan C.;Postma, Dirkje S.;Boomsma, Dorret I.;Gauderman, W. James;Hassanein, Mohamed T.;Lindgren, Cecilia M.;Magi, Reedik;Boreham, Colin A. G.;Neville, Charlotte E.;Moreno, Luis A.;Elliott, Paul;Pouta, Anneli;Hartikainen, Anna-Liisa;Li, Mingyao;Raitakari, Olli;Lehtimaki, Terho;Eriksson, Johan G.;Palotie, Aarno;Dallongeville, Jean;Das, Shikta;Deloukas, Panos;McMahon, George;Ring, Susan M.;Kemp, John P.;Buxton, Jessica L.;Blakemore, Alexandra I. F.;Bustamante, Mariona;Guxens, Monica;Hirschhorn, Joel N.;Gillman, Matthew W.;Kreiner-Moller, Eskil;Bisgaard, Hans;Gilliland, Frank D.;Heinrich, Joachim;Wheeler, Eleanor;Barroso, Ines;O'Rahilly, Stephen;Meirhaeghe, Aline;Sorensen, Thorkild I. A.;Power, Chris;Palmer, Lyle J.;Hinney, Anke;Widen, Elisabeth;Farooqi, I. Sadaf;McCarthy, Mark I.;Froguel, Philippe;Meyre, David;Hebebrand, Johannes;Jarvelin, Marjo-Riitta;Jaddoe, Vincent W. V.;Smith, George Davey;Hakonarson, Hakon;Grant, Struan F. A.
多种遗传变异与成人肥胖和少数儿童严重肥胖相关;然而，在确定常见早发性肥胖的遗传影响方面进展较少。我们对14项研究进行了北美-澳大利亚-欧洲协作荟萃分析，这些研究包括欧洲血统的5，530例病例（体重指数（BMI）≥ 95百分位数）和8，318例对照（BMI <50百分位数）。将产生P <5 × 10 − 6关联的8个新信号推进到9个独立数据集（n = 2，818例病例和4，083例对照）我们观察到两个基因座产生全基因组显著的组合P值，即13q14上的OLFM 4附近（rs9568856; P = 1.82 × 10 − 9; OR = 1.22）和17q21上的HOXB 5（rs9299; P = 3.54 × 10 − 9; OR = 1.14）。当包括两个极端儿童肥胖队列（n = 2，214例和2，674例对照）时，两个位点继续显示相关性。最后，这两个位点在成人BMI的GIANT荟萃分析中产生了方向一致的关联。
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made to establish genetic influences on common early-onset obesity. We performed a North American-Australian-European collaborative meta-analysis of fourteen studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight novel signals yielding association with P < 5×10−6 in to nine independent datasets (n = 2,818 cases and 4,083 controls) we observed two loci that yielded a genome wide significant combined P-value, namely near OLFM4 on 13q14 (rs9568856; P=1.82×10−9; OR=1.22) and within HOXB5 on 17q21 (rs9299; P=3.54×10−9; OR=1.14). Both loci continued to show association when including two extreme childhood obesity cohorts (n = 2,214 cases and 2,674 controls). Finally, these two loci yielded directionally consistent associations in the GIANT meta-analysis of adult BMI.
登录
查看更多内容
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
7.7
作者：
den Hoed M;Ekelund U;Brage S;Grontved A;Zhao JH;Sharp SJ;Ong KK;Wareham NJ;Loos RJ
通讯作者：
Loos RJ
影响因子：
2.9
作者：
Abdullahi, Mohamed;Annibale, Bruno;Severi, Carola
通讯作者：
Severi, Carola
肥胖相关基因座在全基因组关联研究中鉴定出的作用在小儿BMI的测定中。
影响因子：
6.9
作者：
Zhao, Jianhua;Bradfield, Jonathan P.;Li, Mingyao;Wang, Kai;Zhang, Haitao;Kim, Cecilia E.;Annaiah, Kiran;Glessner, Joseph T.;Thomas, Kelly;Garris, Maria;Frackelton, Edward C.;Otieno, F. George;Shaner, Julie L.;Smith, Ryan M.;Chiavacci, Rosetta M.;Berkowitz, Robert I.;Hakonarson, Hakon;Grant, Struan F. A.
通讯作者：
Grant, Struan F. A.
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.