Preparation and characterization of chitosan nanoparticles as the delivery system for tuberose fragrance
Preparation and characterization of chitosan nanoparticles as the delivery system for tuberose fragrance
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晚香玉香料传递系统壳聚糖纳米颗粒的制备及表征
DOI：
10.1002/ffj.3174
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Zhou Rujun
中科院分区：
文献类型：
--
作者：
Xiao Zuobing;Tian Ting;Hu Jing;Wang Mingxi;Zhou Rujun
壳聚糖(CS)在医药领域具有无毒、生物相容性和抗菌活性。香气是由大量不同的香料和气味物质按特定比例混合而成。然而，它们的主要成分是不稳定和挥发性的。大多数挥发性香料在制造、储存和使用香水或带香气的消费品过程中很容易流失。本研究通过乳化体系中的离子凝胶化，将块茎糖香料(TF)包埋在CS纳米粒(TC-NPs)中。详细考察了壳聚糖与三聚磷酸盐(TPP)的质量比、壳聚糖和转铁蛋白的浓度等反应条件对纳米粒子性能(粒径和Zeta电位)的影响。采用透射电子显微镜、动态光散射、傅立叶变换红外光谱、气相色谱-质谱仪、热重分析等方法对纳米TC-NP进行了表征。当CS/TPP质量比为5：1、CS浓度为1.5 mg/ml、Tf含量为100%时，可制得粒径为174 nm的TC-NPs。FTIR表明，Tf可以通过分子间作用力和氢键与CS作用。热重分析表明，TC-NPs的热稳定性较Tf有较大提高，Tf负载量为29.5%。GC-MS分析表明，Tf中90%的香气已被包埋在TC-NPs中。用火焰离子化检测器(FID)进行气相色谱分析，结果表明，加热30h后，纳米粒释放出的芳香成分含量远低于普通粉，而TC-纳米粒的抗菌活性高于普通粉。TC-NPs对细胞的毒性较低。结果表明，CS-NPs是一种多功能香料载体材料。版权所有©2013 John Wiley&Sons，Ltd.
Chitosan (CS) exhibits non-toxicity, biocompatibility and antibacterial activity in the pharmaceutical field. Fragrance is obtained by blending a large number of different spices and odorous materials in a specific ratio. However, their main ingredients are labile and volatile. Most volatile fragrances are easily lost during manufacture, storage and use of the perfumes or the perfumed consumer products. In this study, tuberose fragrance (TF) was encapsulated inside CS nanoparticles (TC-NPs) via the ionic gelification in emulsion system. The influence of reaction conditions, such as weight ratio of CS to tripolyphosphate (TPP) as well as CS and TF concentration, on the properties of nanoparticles (particle size and zeta potential) was investigated in detail. TC-NPs were characterized with transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transformation infrared spectroscopy (FTIR), gas chromatography–mass spectrometry (GC–MS) and thermogravimetric analysis (TGA). TC-NPs (174 nm) were obtained with the weight ratio of CS/TPP 5:1, 1.5 mg/ml CS and 100% TF. FTIR demonstrated that TF can be functioned with CS via intermolecular forces and hydrogen bonds. TGA displayed that the thermal stability of TC-NPs was improved compared with that of TF and that TF loading capacity was 29.5%. GC–MS showed that 90% fragrances in TF had been encapsulated into TC-NPs. GC with flame ionization detector (FID) displayed that the contents of fragrant components released from NPs were much less than that of TF after heating for 30 h. The antimicrobial activities of TC-NPs were higher than that of TF. TC-NPs displayed lower cytotoxicity to the cells. It is shown that CS-NPs is a multifunctional carrier material for fragrance. Copyright © 2013 John Wiley & Sons, Ltd.
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