A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses.
A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses.
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基于肽的病毒灭活剂可抑制怀孕小鼠和胎儿的寨卡病毒感染
DOI：
10.1038/ncomms15672
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发表时间：
2017-07-25
影响因子：
16.6
通讯作者：
Lu L
中科院分区：
文献类型：
--
作者：
Yu Y;Deng YQ;Zou P;Wang Q;Dai Y;Yu F;Du L;Zhang NN;Tian M;Hao JN;Meng Y;Li Y;Zhou X;Fuk-Woo Chan J;Yuen KY;Qin CF;Jiang S;Lu L
Zika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has spread rapidly to more than 70 countries and territories. However, no specific vaccines or antiviral drugs are currently available to prevent or treat ZIKV infection. Here we report that a synthetic peptide derived from the stem region of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and other flaviviruses in vitro. We show that Z2 interacts with ZIKV surface protein and disrupts the integrity of the viral membrane. Z2 can penetrate the placental barrier to enter fetal tissues and is safe for use in pregnant mice. Intraperitoneal administration of Z2 inhibits vertical transmission of ZIKV in pregnant C57BL/6 mice and protects type I or type I/II interferon receptor-deficient mice against lethal ZIKV challenge. Thus, Z2 has potential to be further developed as an antiviral treatment against ZIKV infection in high-risk populations, particularly pregnant women. Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.
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影响因子：
30.3
作者：
Barrows NJ;Campos RK;Powell ST;Prasanth KR;Schott-Lerner G;Soto-Acosta R;Galarza-Muñoz G;McGrath EL;Urrabaz-Garza R;Gao J;Wu P;Menon R;Saade G;Fernandez-Salas I;Rossi SL;Vasilakis N;Routh A;Bradrick SS;Garcia-Blanco MA
通讯作者：
Garcia-Blanco MA
影响因子：
64.8
作者：
Govero J;Esakky P;Scheaffer SM;Fernandez E;Drury A;Platt DJ;Gorman MJ;Richner JM;Caine EA;Salazar V;Moley KH;Diamond MS
通讯作者：
Diamond MS
影响因子：
64.5
作者：
Kuhn, RJ;Zhang, W;Strauss, JH
通讯作者：
Strauss, JH
DOI：
10.1006/bbrc.1993.2078
发表时间：
1993-09-15
影响因子：
3.1
作者：
JIANG, SB;LIN, K;NEURATH, AR
通讯作者：
NEURATH, AR
影响因子：
4.8
作者：
Bothner, B;Dong, XF;Siuzdak, G
通讯作者：
Siuzdak, G