A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder.
A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder.
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DOI：
10.1111/bdi.12985
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发表时间：
2021-05
影响因子：
5.4
通讯作者：
Tseng WL
中科院分区：
文献类型：
--
作者：
Ross AJ;Roule AL;Deveney CM;Towbin KE;Brotman MA;Leibenluft E;Tseng WL
与健康志愿者（HV）相比，双相情感障碍（BD）青少年的挫折感与注意力受损、唤醒增强和更大的不快乐有关。很少有人知道BD青少年在应对挫折时的功能连接。这项探索性研究比较了BD青少年和HV的注意力能力，自我报告的影响，和功能连接在一个令人沮丧的注意力任务。20名BD（法师=15.86）和20名HV（法师=15.55）青年在接受功能磁共振成像（fMRI）扫描时完成了一个令人沮丧的注意范式。通过向参与者提供被操纵的反馈来诱导挫折感。我们研究功能连接组的差异，使用额下回（IFG）和杏仁核作为种子。我们探讨了任务表现（准确性，反应时间），自我报告的挫折和不快乐，以及这些变量与抑郁和躁狂症状之间的相关性。BD青少年，相对于HV，表现出增加的功能连接IFG和腹内侧前额叶皮层（vmPFC）之间的反馈处理过程中，IFG和海马旁回（PHG）/导水管周围灰质（PAG）在注意力定向挫折。BD与HV青少年在挫折后的注意力定向过程中表现出杏仁核和小脑之间的连接性下降。在各组中，较高的抑郁症状与挫折下自我报告的更大的不快乐有关。在BD中，较高的躁狂症状与挫折下较差的准确性相关。增加IFG-vmPFC连接在BD处理过程中的非沮丧和沮丧的反馈可能反映了提高敏感性的积极和消极的valenced刺激。挫折后BD中IFG-PAG/PHG连接的升高可能表明注意力网络的更多招募，以调节唤醒和维持目标导向行为。
Frustration is associated with impaired attention, heightened arousal, and greater unhappiness in youths with bipolar disorder (BD) vs. healthy volunteers (HV). Little is known about functional connectivity in BD youths in response to frustration. This exploratory study compared BD youths and HV on attentional abilities, self-reported affect, and functional connectivity during a frustrating attentional task. 20 BD (Mage=15.86) and 20 HV (Mage=15.55) youths completed a frustrating attention paradigm while undergoing functional magnetic resonance imaging (fMRI) scanning. Frustration was induced by providing participants with rigged feedback. We examined functional connectivity group differences using the inferior frontal gyrus (IFG) and amygdala as seeds. We explored task performance (accuracy, reaction time), self-reported frustration and unhappiness, and correlations between these variables and depressive and manic symptoms. BD youths, relative to HV, exhibited increased functional connectivity between IFG and ventromedial prefrontal cortex (vmPFC) during feedback processing and between IFG and parahippocampal gyrus (PHG)/periaqueductal gray (PAG) during attention orienting following frustration. BD vs. HV youths showed decreased connectivity between the amygdala and cerebellum during attention orienting following frustration. Across groups, higher depressive symptoms were associated with greater self-reported unhappiness under frustration. In BD, higher manic symptoms were associated with poorer accuracy under frustration. Increased IFG-vmPFC connectivity in BD during processing of non-frustrating and frustrating feedback may reflect heightened sensitivity to positively and negatively valenced stimuli. Elevated IFG-PAG/PHG connectivity in BD following frustration may suggest greater recruitment of attention network to regulate arousal and maintain goal-directed behavior.
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影响因子：
5.4
作者：
Goldstein BI;Birmaher B;Carlson GA;DelBello MP;Findling RL;Fristad M;Kowatch RA;Miklowitz DJ;Nery FG;Perez-Algorta G;Van Meter A;Zeni CP;Correll CU;Kim HW;Wozniak J;Chang KD;Hillegers M;Youngstrom EA
通讯作者：
Youngstrom EA
从杏仁核中的电路到行为。
影响因子：
64.8
作者：
Janak PH;Tye KM
通讯作者：
Tye KM
影响因子：
4.7
作者：
Haller SP;Kircanski K;Stoddard J;White LK;Chen G;Sharif-Askary B;Zhang S;Towbin KE;Pine DS;Leibenluft E;Brotman MA
通讯作者：
Brotman MA
影响因子：
1.9
作者：
Blair, Robert J. R.
通讯作者：
Blair, Robert J. R.
影响因子：
5.7
作者：
McLaren, Donald G.;Ries, Michele L.;Xu, Guofan;Johnson, Sterling C.
通讯作者：
Johnson, Sterling C.