Teasing apart tangrams: testing hippocampal pattern separation with a collaborative referencing paradigm.
Teasing apart tangrams: testing hippocampal pattern separation with a collaborative referencing paradigm.
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DOI：
10.1002/hipo.20967
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发表时间：
2012-05
期刊：
影响因子：
3.5
通讯作者：
Cohen, Neal J.
中科院分区：
文献类型：
--
作者：
Duff, Melissa C.;Warren, David E.;Gupta, Rupa;Vidal, Juan Pablo Benabe;Tranel, Daniel;Cohen, Neal J.
海马体和内侧颞叶皮层（MTLC）都有助于长期记忆。虽然他们的贡献被认为是可分离的，但每个区域支持的表征的性质仍不清楚。互补学习系统（CLS）建模方法表明，海马体以更稀疏的方式表示重叠信息，因此比MTLC更分离。我们使用协作参考范式来测试这一预测，即海马体健忘症患者和合作伙伴共同开发和使用跨扩展交互的一组抽象视觉刺激（七彩图）的独特标签。以前，我们报道过失忆症患者在图形概念不同时表现出完整的学习能力。在这里，我们操纵了视觉相似性的程度；一半的刺激是不同的（例如，骆驼，长颈鹿），一半是相似的（例如，鸟类）。我们假设，虽然患者对不同的七巧图没有什么困难（快速到达独特和简洁的标签），但他们无法快速形成高度相似的视觉模式的不同表征。与这一预测一致的是，病人和健康的和脑损伤的参与者在不同的七巧板上表现出相似的学习速度，但海马区病人更难学习类似的七巧板，这反映在他们用更多的单词来描述每个相似的卡片上。这一结果支持了CLS模型关于海马特化模式分离的核心主张，并表明我们的协作参考范式可能是观察复杂表征扩展编码的有用工具。
The hippocampus and the medial temporal lobe cortex (MTLC) both contribute to long-term memory. While their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling approach suggests that hippocampus represents overlapping information in a sparser and therefore more separated fashion than MTLC. We tested this prediction using a collaborative referencing paradigm whereby hippocampal amnesic patients and a partner work together to develop and use unique labels for a set of abstract visual stimuli (tangrams) across extended interactions. Previously, we reported that amnesic patients demonstrate intact learning when the tangrams are conceptually dissimilar. Here, we manipulated the degree of visual similarity; half of the stimuli were dissimilar to one another (e.g., camel, giraffe), and half were similar (e.g., birds). We hypothesized that while patients would have little difficulty with the dissimiliar tangrams (quickly arriving at unique and concise labels) they would be unable to rapidly form distinct representations of highly similar visual patterns. Consistent with this prediction, patients and both healthy and brain-damaged comparison participants showed similar rates of learning for dissimilar tangrams, but the similar tangrams proved more difficult for hippocampal patients as reflected in the greater number of words they used to describe each similar card. This result supports the CLS model’s central claim of hippocampal specialization for pattern separation, and suggests that our collaborative referencing paradigm may be a useful tool for observing extended encoding of complex representations.
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影响因子：
3.5
作者：
Norman, Kenneth A.
通讯作者：
Norman, Kenneth A.
影响因子：
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作者：
Duff, Melissa C.;Hengst, Julie A.;Cohen, Neal J.
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Cohen, Neal J.
DOI：
10.1080/13803390590949287
发表时间：
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