Folate intake and breast cancer mortality in a cohort of Swedish women.
Folate intake and breast cancer mortality in a cohort of Swedish women.
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DOI：
10.1007/s10549-011-1838-y
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发表时间：
2012-02
影响因子：
3.8
通讯作者：
Wolk, Alicja
中科院分区：
文献类型：
--
作者：
Harris, Holly R.;Bergkvist, Leif;Wolk, Alicja
叶酸可能通过其在单碳代谢中的作用影响乳腺癌的发生和进展。然而，关于叶酸与乳腺癌生存之间关系的流行病学数据有限。我们调查了以人群为基础的瑞典乳房x线摄影队列中3116名诊断为乳腺癌的妇女的饮食叶酸摄入量是否与生存率相关。1987年，参与者完成了一份包含67个项目的食物频率调查问卷。使用Cox比例风险模型计算乳腺癌死亡和任何原因死亡的风险比（hr）和95%置信区间（95% ci）。在1987年至2008年的25,716人年随访期间，有852人死亡，其中381人死于乳腺癌。饮食中叶酸的摄入量与乳腺癌和总体死亡率呈负相关。与叶酸摄入量最低的四分位数相比，叶酸摄入量最高的四分位数女性死于乳腺癌的多变量HR （95% CI）为0.78 (0.58-1.03)（p趋势= 0.03）。任何原因死亡的相应HR （95% CI）为0.79 （0.66-0.96；p趋势= 0.004）。与最高和最低四分位数相比，饮食中叶酸摄入量与乳腺癌死亡之间的保护性关联在er阴性肿瘤患者中最强（HR = 0.42; 95% = CI 0.22-0.79； p趋势= 0.01）。我们的研究结果表明，在乳腺癌诊断前摄入叶酸可能会改善乳腺癌和总体生存率。虽然这些发现需要在未来的研究中得到证实，但它们确实提供了保证，即在我们的人群中观察到的膳食叶酸摄入量不会对乳腺癌后的生存产生不利影响。
Folate may influence breast cancer development and progression through its role in one-carbon metabolism. However, epidemiologic data on the relation between folate and breast cancer survival are limited. We investigated whether dietary folate intake was associated with survival in 3,116 women diagnosed with breast cancer in the population-based Swedish Mammography Cohort. Participants completed a 67-item food frequency questionnaire in 1987. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for death from breast cancer and death from any cause. During 25,716 person-years of follow-up from 1987 to 2008, there were 852 deaths with 381 breast cancer deaths. Dietary folate intake was inversely associated with breast cancer and overall mortality. Women in the highest quartile of folate intake had a multivariable HR (95% CI) of death from breast cancer of 0.78 (0.58–1.03) compared to those in the lowest quartile (Ptrend = 0.03). The corresponding HR (95% CI) for death from any cause was 0.79 (0.66–0.96; Ptrend = 0.004). The protective association between dietary folate intake and breast cancer death was strongest among those with ER-negative tumors (HR = 0.42; 95% = CI 0.22–0.79; Ptrend = 0.01) comparing the highest to lowest quartile. Our findings suggest that folate intake before breast cancer diagnosis may improve breast cancer and overall survival. While these findings need to be confirmed in future studies, they do offer assurance that dietary folate intake at the levels observed in our population does not unfavorably affect survival after breast cancer.
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影响因子：
5
作者：
WILLETT, W;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
影响因子：
2.9
作者：
McEligot, Archana Jaiswal;Largent, Joan;Anton-Culver, Hoda
通讯作者：
Anton-Culver, Hoda
影响因子：
120.7
作者：
Wolk, Alicja;Larsson, Susanna C.;Ekman, Peter
通讯作者：
Ekman, Peter
影响因子：
7.1
作者：
Lin, Jennifer;Lee, I-Min;Zhang, Shumin M.
通讯作者：
Zhang, Shumin M.
影响因子：
4.2
作者：
Kim, YI
通讯作者：
Kim, YI