Fast diffusion kurtosis imaging of fibrotic mouse kidneys.
Fast diffusion kurtosis imaging of fibrotic mouse kidneys.
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DOI：
10.1002/nbm.3623
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发表时间：
2016-12
影响因子：
2.9
通讯作者：
Hansen, B.
中科院分区：
文献类型：
--
作者：
Kjolby, B. F.;Khan, A. R.;Chuhutin, A.;Pedersen, L.;Jensen, J. B.;Jakobsen, S.;Zeidler, D.;Sangill, R.;Nyengaard, J. R.;Jespersen, S. N.;Hansen, B.
扩散峰度成像（DKI）对组织的微观结构敏感，因此可用于诊断和监测脑和身体器官的疾病。一般来说，由于身体成分不均匀，体内的弥散MRI（dMRI）具有挑战性，可能会因化学位移和磁化率差异而导致图像伪影。此外，腹部具有强烈的生理因素（例如呼吸、心跳、血流），这可能严重降低图像质量，特别是当采用dMRI中典型的回波平面成像时。总的来说，这些具有挑战性的测量条件阻碍了DKI在体内的使用和探索。传统上DKI所需的大量数据和有效探测峰度状态所需的b值处的低信噪比进一步加剧了这种障碍。最近引入的快速DKI技术通过大幅降低数据要求来减少体内DKI的挑战，使得例如触发和屏气技术可以应用于整个DKI采集，而不会导致不可行的扫描时间。身体DKI可能具有直接临床价值的一种常见病理状况是肾纤维化，其导致器官微观结构的进行性变化。由于其对微观结构的敏感性，DKI是非侵入性评估方法的明显候选者。我们目前的临床前证据表明，快速获得的张量衍生的平均峰度（W）区分中度纤维化肾脏健康对照。通过组织学证实了纤维化的存在和程度，这也表明纤维化是组间观察到的DKI差异的主要驱动因素。因此，我们得出结论，快速峰度是一个可能的候选人的MRI为基础的方法检测和监测肾纤维化。我们基于使用在正常人肾脏中在3T下采集的数据进行的b值优化，提供了人体快速肾脏DKI的方案建议。
Diffusion kurtosis imaging (DKI) is sensitive to tissue microstructure and may therefore be useful in the diagnosis and monitoring of disease in brain and body organs. Generally, diffusion MRI (dMRI) in the body is challenging due to heterogeneous body composition that can cause image artifacts due to chemical shifts and susceptibility differences. Additionally, the abdomen has a strong presence of physiological factors (e.g. breath, heartbeat, blood flow), which may severely reduce image quality, especially when echo-planar imaging is employed as is typical in dMRI. Collectively, these challenging measurement conditions impede the use and exploration of DKI in the body. This impediment is further exacerbated by the traditionally large amount of data required for DKI and low signal-to-noise ratio at the b-values needed to effectively probe the kurtosis regime. Recently introduced fast DKI techniques reduce the challenge of DKI in the body by lowering the data requirement substantially so that e.g. triggering and breath hold techniques may be applied for the entire DKI acquisition without causing unfeasible scan times. One common pathologic condition where body DKI may be of immediate clinical value is kidney fibrosis, which causes a progressing change in organ microstructure. With its sensitivity to microstructure, DKI is an obvious candidate for a non-invasive evaluation method. We present preclinical evidence that the rapidly obtainable tensor-derived mean kurtosis (W̄) distinguishes moderately fibrotic kidneys from healthy controls. The presence and degree of fibrosis are confirmed by histology, which also indicates fibrosis as the main driver behind the DKI differences observed between groups. We therefore conclude that fast kurtosis is a likely candidate for an MRI based method for detection and monitoring of renal fibrosis. We provide protocol recommendations for fast renal DKI in humans based on a b-value optimization performed using data acquired at 3T in normal human kidney.
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