Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.
Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.
复制标题
DOI：
10.3390/mi12080972
复制
发表时间：
2021-08-17
期刊：
影响因子：
3.4
通讯作者：
Pancrazio JJ
中科院分区：
文献类型：
--
作者：
Usoro JO;Sturgill BS;Musselman KC;Capadona JR;Pancrazio JJ
虽然微电极阵列(MEA)有望阐明功能性神经电路，并作为皮质神经假体的基础，但设计和展示长期可靠的技术仍然是一个挑战。许多研究报告了“慢性”数据，但与实验工作相对应的实际时间跨度和绩效衡量标准各不相同。在这项研究中，我们回顾了构成慢性研究的实验持续时间，涉及一系列MEA类型和动物物种，以了解已报道的研究持续时间的广泛变异性。对于啮齿动物，这是慢性研究中最常用的动物模型，我们检查了不同阵列类型的活性电极产量(AEY)，作为研究持续时间差异的一种手段，以及调查和解释定制设备与传统MEA相比的性能。我们观察到，在植入商用设备的啮齿动物模型中，在慢性着床期和AEY线性衰减的物种内存在广泛的差异。这些观察结果为比较新技术的性能提供了一个基准，并强调了长期MEA研究的一致性的必要性。此外，为了充分获得慢性条件下的性能，非生物失效模式的持续时间、留置探头诱导的生物过程以及设备的预期应用是关键决定因素。
While microelectrode arrays (MEAs) offer the promise of elucidating functional neural circuitry and serve as the basis for a cortical neuroprosthesis, the challenge of designing and demonstrating chronically reliable technology remains. Numerous studies report “chronic” data but the actual time spans and performance measures corresponding to the experimental work vary. In this study, we reviewed the experimental durations that constitute chronic studies across a range of MEA types and animal species to gain an understanding of the widespread variability in reported study duration. For rodents, which are the most commonly used animal model in chronic studies, we examined active electrode yield (AEY) for different array types as a means to contextualize the study duration variance, as well as investigate and interpret the performance of custom devices in comparison to conventional MEAs. We observed wide-spread variance within species for the chronic implantation period and an AEY that decayed linearly in rodent models that implanted commercially-available devices. These observations provide a benchmark for comparing the performance of new technologies and highlight the need for consistency in chronic MEA studies. Additionally, to fully derive performance under chronic conditions, the duration of abiotic failure modes, biological processes induced by indwelling probes, and intended application of the device are key determinants.
登录
查看更多内容
影响因子：
4
作者：
Barrese JC;Aceros J;Donoghue JP
通讯作者：
Donoghue JP
影响因子：
4.9
作者：
Cogan, SF;Edell, DJ;Edell, R
通讯作者：
Edell, R
影响因子：
5.6
作者：
Carriero, Giovanni;Arcieri, Salvatore;de Curtis, Marco
通讯作者：
de Curtis, Marco
影响因子：
5.3
作者：
AGNEW, WF;YUEN, TGH;BULLARA, LA
通讯作者：
BULLARA, LA
影响因子：
3
作者：
Chen, You-Yin;Lai, Hsin-Yi;Lin, Si-Yue
通讯作者：
Lin, Si-Yue