What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory.
What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory.
复制标题
DOI：
10.1016/j.neuropsychologia.2012.07.034
复制
发表时间：
2012-11
期刊：
影响因子：
2.6
通讯作者：
Warburton EC
中科院分区：
文献类型：
--
作者：
Brown MW;Barker GR;Aggleton JP;Warburton EC
药理学研究的结果，已调查参与识别记忆的大脑的特定区域进行审查。特别强调的审查关注这些研究表明，在识别记忆中的作用的嗅周皮层。大多数研究涉及大鼠，大多数研究对象的识别记忆。药理学研究提供了大量的证据支持嗅周皮层在物体识别记忆的获得、巩固和提取中的重要作用。这些研究提供了越来越详细的证据，涉及神经递质系统和潜在的细胞内机制参与识别记忆过程。他们提供的证据支持突触弱化作为一个主要的突触可塑性的过程中，周围皮层的物体识别记忆。他们还提供了确凿的证据，证明有一个以上的突触可塑性过程参与。已证明的必要性，以长期识别记忆的细胞内信号机制相关的突触修饰内嗅周皮层建立了一个中心的作用，该地区的信息存储这种记忆。因此，嗅周皮层被确立为信息储存场所，而不仅仅是一个处理站。药理学研究也提供了新的证据，说明海马体和内侧前额叶皮层等其他区域在不同类型的识别记忆任务（包括空间或时间成分）中的详细作用。在这样做的过程中，他们还进一步确定了嗅周皮层对这些任务的贡献。到目前为止，似乎嗅周皮层对联想记忆和时间顺序记忆的贡献反映了简单物体识别记忆的贡献，即嗅周皮层提供关于物体及其先前出现的信息（新奇/熟悉）。嗅周皮层在识别记忆中的作用。特定脑区的选择性药物干预对再认记忆的影响。β-内酰胺类和胆碱能拮抗剂及靶向细胞内信号传导机制的化合物产生的损伤。3.对物体、原地物体和时间顺序识别记忆的影响。
Findings of pharmacological studies that have investigated the involvement of specific regions of the brain in recognition memory are reviewed. The particular emphasis of the review concerns what such studies indicate concerning the role of the perirhinal cortex in recognition memory. Most of the studies involve rats and most have investigated recognition memory for objects. Pharmacological studies provide a large body of evidence supporting the essential role of the perirhinal cortex in the acquisition, consolidation and retrieval of object recognition memory. Such studies provide increasingly detailed evidence concerning both the neurotransmitter systems and the underlying intracellular mechanisms involved in recognition memory processes. They have provided evidence in support of synaptic weakening as a major synaptic plastic process within perirhinal cortex underlying object recognition memory. They have also supplied confirmatory evidence that that there is more than one synaptic plastic process involved. The demonstrated necessity to long-term recognition memory of intracellular signalling mechanisms related to synaptic modification within perirhinal cortex establishes a central role for the region in the information storage underlying such memory. Perirhinal cortex is thereby established as an information storage site rather than solely a processing station. Pharmacological studies have also supplied new evidence concerning the detailed roles of other regions, including the hippocampus and the medial prefrontal cortex in different types of recognition memory tasks that include a spatial or temporal component. In so doing, they have also further defined the contribution of perirhinal cortex to such tasks. To date it appears that the contribution of perirhinal cortex to associative and temporal order memory reflects that in simple object recognition memory, namely that perirhinal cortex provides information concerning objects and their prior occurrence (novelty/familiarity). ► Perirhinal cortex role in recognition memory. ► Effect of selective pharmacological interventions in specific brain regions on recognition memory. ► Impairments produced by glutamatergic & cholinergic antagonists & compounds targeting intracellular signalling mechanisms. ► Effects on object, object-in-place and temporal order recognition memory.
登录
查看更多内容
影响因子：
3.4
作者：
Barker, G. R. I.;Warburton, E. C.
通讯作者：
Warburton, E. C.
影响因子：
2
作者：
Balderas, Israela;Rodriguez-Ortiz, Carlos J.;Bermudez-Rattoni, Federico
通讯作者：
Bermudez-Rattoni, Federico
影响因子：
5.3
作者：
Bartko, Susan J.;Winters, Boyer D.;Bussey, Timothy J.
通讯作者：
Bussey, Timothy J.
影响因子：
7.8
作者：
Androulidakis, Zacharias;Lulham, Andrew;Brown, Malcolm W.
通讯作者：
Brown, Malcolm W.
影响因子：
2
作者：
Baker, KB;Kim, JJ
通讯作者：
Kim, JJ