Bipolar I disorder and major depressive disorder show similar brain activation during depression.
Bipolar I disorder and major depressive disorder show similar brain activation during depression.
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DOI：
10.1111/bdi.12225
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发表时间：
2014-11
影响因子：
5.4
通讯作者：
Strakowski SM
中科院分区：
文献类型：
--
作者：
Cerullo MA;Eliassen JC;Smith CT;Fleck DE;Nelson EB;Strawn JR;Lamy M;DelBello MP;Adler CM;Strakowski SM
尽管治疗方法和病程不同，但重性抑郁症（MDD）和双相I型障碍（BP-I）的抑郁症状相似。抑郁症状的这种相似性表明，抑郁症的神经植物性、情绪和认知症状的大脑通路存在显著重叠。在功能性磁共振成像（fMRI）中，这些共享的大脑区域可能会在MDD和BP-I患者中表现出类似的激活。使用fMRI比较抑郁发作期间BP-I（n = 25）和MDD（n = 25）参与者以及25名健康对照（HC）参与者的局部脑激活。在扫描过程中，参与者执行了一项包含情感图片的注意力任务。在观看情绪图像，与BP-I的主题表现出减少激活枕中回，舌回，颞中回相比，这两个主题与MDD和HC参与者。在注意力处理过程中，MDD患者的海马旁、顶叶和中央后回的激活增加。然而，在这些区域中，只有中央后回也表现出MDD和HC参与者之间的差异。在抑郁症期间，BP-I和MDD参与者之间的皮质边缘区没有差异。相反，主要差异发生在初级和次级视觉处理区域，与重度抑郁症相比，BP-I中这些区域的激活减少。这些差异是由BP-I参与者中观察到的激活异常减少引起的。在BP-I参与者的情绪状态研究中，后部激活变化是一个常见的发现。
Despite different treatments and course of illness, depressive symptoms appear similar in major depressive disorder (MDD) and bipolar I disorder (BP-I). This similarity of depressive symptoms suggests significant overlap in brain pathways underlying neurovegetative, mood, and cognitive symptoms of depression. These shared brain regions might be expected to exhibit similar activation in individuals with MDD and BP-I during functional magnetic resonance imaging (fMRI). fMRI was used to compare regional brain activation in participants with BP-I (n = 25) and MDD (n = 25) during a depressive episode as well as 25 healthy comparison (HC) participants. During the scans, participants performed an attentional task that incorporated emotional pictures. During the viewing of emotional images, subjects with BP-I showed decreased activation in the middle occipital gyrus, lingual gyrus, and middle temporal gyrus compared to both subjects with MDD and HC participants. During attentional processing, participants with MDD had increased activation in the parahippocampus, parietal lobe, and postcentral gyrus. However, among these regions, only the postcentral gyrus also showed differences between MDD and HC participants. No differences in cortico-limbic regions were found between participants with BP-I and MDD during depression. Instead, the major differences occurred in primary and secondary visual processing regions with decreased activation in these regions in BP-I compared to major depression. These differences were driven by abnormal decreases in activation seen in the participants with BP-I. Posterior activation changes are a common finding in studies across mood states in participants with BP-I.
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影响因子：
10.6
作者：
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影响因子：
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作者：
Almeida, Jorge R. C.;Mechelli, Andrea;Hassel, Stefanie;Versace, Amelia;Kupfer, David J.;Phillips, Mary L.
通讯作者：
Phillips, Mary L.