The EMIF-AD PreclinAD study: study design and baseline cohort overview.
The EMIF-AD PreclinAD study: study design and baseline cohort overview.
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DOI：
10.1186/s13195-018-0406-7
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发表时间：
2018-08-04
期刊：
影响因子：
--
通讯作者：
Visser PJ
中科院分区：
文献类型：
--
作者：
Konijnenberg E;Carter SF;Ten Kate M;den Braber A;Tomassen J;Amadi C;Wesselman L;Nguyen HT;van de Kreeke JA;Yaqub M;Demuru M;Mulder SD;Hillebrand A;Bouwman FH;Teunissen CE;Serné EH;Moll AC;Verbraak FD;Hinz R;Pendleton N;Lammertsma AA;van Berckel BNM;Barkhof F;Boomsma DI;Scheltens P;Herholz K;Visser PJ
淀粉样蛋白病理学是阿尔茨海默病（AD）的病理学标志，并且可以在临床痴呆之前数十年。到目前为止，淀粉样蛋白病理学如何导致认知障碍和痴呆仍不清楚。要设计AD预防试验，关键是纳入淀粉样蛋白病理学高危的认知正常受试者，并找到这些受试者中认知功能下降的预测因子。这些目标可以通过靶向双胞胎来实现，另外还可以识别淀粉样蛋白病理学、其他AD生物标志物和认知能力下降的遗传和环境途径。从2014年12月至2017年10月，我们从正在进行的曼彻斯特和纽卡斯尔年龄和认知表现研究队列以及荷兰双胞胎登记中招募了60岁及以上的认知正常参与者。在曼彻斯特，我们包括了单个个体，在阿姆斯特丹，我们包括了同卵双胞胎。在基线时，参与者完成神经心理学测试和问卷调查，并接受体格检查，血液采样，颈动脉超声，结构和静息状态功能性脑磁共振成像，以及动态淀粉样蛋白正电子发射断层扫描（PET）与[18F] flutemetetamine扫描。此外，双胞胎队列进行腰椎穿刺脑脊液收集，颊细胞收集，脑磁图，光学相干断层扫描和视网膜成像。我们纳入了285名参与者，平均年龄为74.8 ± 9.7岁，其中64%为女性。58名参与者（22%）有异常淀粉样蛋白PET扫描。已经建立了认知正常老年人的丰富基线数据集，以估计淀粉样蛋白病理学和未来认知下降的风险因素和生物标志物。本文的在线版本（10.1186/s13195-018-0406-7）包含补充材料，可供授权用户使用。
Amyloid pathology is the pathological hallmark in Alzheimer’s disease (AD) and can precede clinical dementia by decades. So far it remains unclear how amyloid pathology leads to cognitive impairment and dementia. To design AD prevention trials it is key to include cognitively normal subjects at high risk for amyloid pathology and to find predictors of cognitive decline in these subjects. These goals can be accomplished by targeting twins, with additional benefits to identify genetic and environmental pathways for amyloid pathology, other AD biomarkers, and cognitive decline. From December 2014 to October 2017 we enrolled cognitively normal participants aged 60 years and older from the ongoing Manchester and Newcastle Age and Cognitive Performance Research Cohort and the Netherlands Twins Register. In Manchester we included single individuals, and in Amsterdam monozygotic twin pairs. At baseline, participants completed neuropsychological tests and questionnaires, and underwent physical examination, blood sampling, ultrasound of the carotid arteries, structural and resting state functional brain magnetic resonance imaging, and dynamic amyloid positron emission tomography (PET) scanning with [18F]flutemetamol. In addition, the twin cohort underwent lumbar puncture for cerebrospinal fluid collection, buccal cell collection, magnetoencephalography, optical coherence tomography, and retinal imaging. We included 285 participants, who were on average 74.8 ± 9.7 years old, 64% female. Fifty-eight participants (22%) had an abnormal amyloid PET scan. A rich baseline dataset of cognitively normal elderly individuals has been established to estimate risk factors and biomarkers for amyloid pathology and future cognitive decline. The online version of this article (10.1186/s13195-018-0406-7) contains supplementary material, which is available to authorized users.
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影响因子：
4.8
作者：
Boeve, Bradley F.;Molano, Jennifer R.;Ferman, Tanis J.;Smith, Glenn E.;Lin, Siong-Chi;Bieniek, Kevin;Haidar, Wael;Tippmann-Peikert, Maja;Knopman, David S.;Graff-Radford, Neill R.;Lucas, John A.;Petersen, Ronald C.;Silber, Michael H.
通讯作者：
Silber, Michael H.
影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
0.9
作者：
Boomsma, Dorret I.;de Geus, Eco J. C.;Willemsen, Gonneke
通讯作者：
Willemsen, Gonneke
影响因子：
4
作者：
de Jager, CA;Budge, MM;Clarke, R
通讯作者：
Clarke, R
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.