Stem Cell-Based Therapies in Hearing Loss.
Stem Cell-Based Therapies in Hearing Loss.
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基于干细胞的听力损失疗法
DOI：
10.3389/fcell.2021.730042
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发表时间：
2021
影响因子：
5.5
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
He Z;Ding Y;Mu Y;Xu X;Kong W;Chai R;Chen X
近年来，神经干细胞移植作为一种新的治疗方法，用于补充因疾病（如神经退行性疾病）而受损的特定细胞，受到广泛关注。多项研究证明，神经干细胞移植在多器官中对细胞的活化和再生，修复受损的神经元具有重要的治疗作用。本文介绍了内源性和外源性干细胞的诱导分化方法、外源性干细胞植入内耳的操作及植入后的调控，阐述了干细胞在内耳的相关信号通路，以及各种新材料的临床应用。目前，干细胞治疗仍有局限性，但该技术在治疗听力疾病中的作用已得到广泛认可。随着相关研究的发展，干细胞疗法将在内耳相关疾病的治疗中发挥更大的作用。
In recent years, neural stem cell transplantation has received widespread attention as a new treatment method for supplementing specific cells damaged by disease, such as neurodegenerative diseases. A number of studies have proved that the transplantation of neural stem cells in multiple organs has an important therapeutic effect on activation and regeneration of cells, and restore damaged neurons. This article describes the methods for inducing the differentiation of endogenous and exogenous stem cells, the implantation operation and regulation of exogenous stem cells after implanted into the inner ear, and it elaborates the relevant signal pathways of stem cells in the inner ear, as well as the clinical application of various new materials. At present, stem cell therapy still has limitations, but the role of this technology in the treatment of hearing diseases has been widely recognized. With the development of related research, stem cell therapy will play a greater role in the treatment of diseases related to the inner ear.
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影响因子：
3.7
作者：
Aburto MR;Magariños M;Leon Y;Varela-Nieto I;Sanchez-Calderon H
通讯作者：
Sanchez-Calderon H
干细胞疗法：一种有前景的脑出血治疗方法
影响因子：
3.3
作者：
Gao L;Xu W;Li T;Chen J;Shao A;Yan F;Chen G
通讯作者：
Chen G
DOI：
10.1126/science.1241062
发表时间：
2014-05-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Géléoc GS;Holt JR
通讯作者：
Holt JR
影响因子：
56.9
作者：
Clarke, DL;Johansson, CB;Frisén, J
通讯作者：
Frisén, J
影响因子：
14
作者：
Ankam, Soneela;Lim, Choon Kiat;Yim, Evelyn K. F.
通讯作者：
Yim, Evelyn K. F.