Considerations for Generating Frequency Modulation Waveforms for Fourier Transform-Ion Mobility Experiments.
Considerations for Generating Frequency Modulation Waveforms for Fourier Transform-Ion Mobility Experiments.
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DOI：
10.1021/jasms.2c00168
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发表时间：
2022-10-05
影响因子：
3.2
通讯作者：
Clowers, Brian H.
中科院分区：
文献类型：
--
作者：
Cabrera, Elvin R.;Clowers, Brian H.
通过在频域中投射有关离子群迁移率的信息，时间色散的离子迁移率技术的耦合现在立即与较慢的质量分析器(如离子陷阱)兼容。最近的报告详细介绍了傅里叶变换离子迁移率-质谱仪(FT-IM-MS)实验效率最大化的持续进展，但很少有报告概述实施的实际考虑与传统信号处理技术施加的理论限制之间的交叉。基于傅立叶的多路复用实验的一个重要问题是避免在数据采集期间可能出现的信号混叠作为欠采样信号的乘积。除了探测器采样频率等传统考虑因素外，还必须评估实验质量扫描持续时间施加的限制(即最大可测量漂移时间)，以及用于离子门调制的频率扫描。这项工作旨在将FT-IM-MS实验的基本基础与相关的实验参数联系起来，这些实验参数是在将迁移率域中相对较快的分离与离子陷阱质谱仪常见的较慢的m/z扫描相结合时遇到的。除了阐述适用于FT-IM-MS实验的相关理论外，本报告还重点介绍了混叠信号如何在重建的到达时间分布和计算的迁移率中表现为傅里叶变换后。
By casting the information regarding an ion population’s mobility in the frequency domain, the coupling of time-dispersive ion mobility techniques is now imminently compatible with slower mass analyzers such as ion traps. Recent reports have detailed the continued progress towards maximizing the efficiency of the Fourier transform ion mobility-mass spectrometry (FT-IM-MS) experiments but few reports have outlined the intersection between the practical considerations of implementation against the theoretical limits imposed by traditional signal processing techniques. One of the important concerns for Fourier based multiplexing experiments is avoiding signal aliasing as a product of undersampled signals that may occur during data acquisition. In addition to traditional considerations such as detector sampling frequency, the limitations (i.e. maximum measurable drift time) imposed by experimental mass scan duration, and the frequency sweep used for ion gate modulation must also be assessed. This work aims to connect the fundamental underpinnings of FT-IM-MS experiments and the associated experimental parameters that are encountered when coupling the comparatively fast separations in the mobility domain with the slower m/z scanning common for ion trap mass analyzers. In addition to stating the relevant theory that applies to the FT-IM-MS experiment, this report highlights how aliased signals will manifest post Fourier transform in reconstructed arrival time distributions and calculated mobilities.
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影响因子：
7.4
作者：
McCabe JW;Shirzadeh M;Walker TE;Lin CW;Jones BJ;Wysocki VH;Barondeau DP;Clemmer DE;Laganowsky A;Russell DH
通讯作者：
Russell DH
影响因子：
7.4
作者：
Poltash ML;McCabe JW;Shirzadeh M;Laganowsky A;Clowers BH;Russell DH
通讯作者：
Russell DH
影响因子：
1.8
作者：
McLean, JA;Ruotolo, BT;Russell, DH
通讯作者：
Russell, DH
影响因子：
7.4
作者：
KNORR, FJ;EATHERTON, RL;HILL, HH
通讯作者：
HILL, HH
DOI：
10.1021/jasms.1c00184
发表时间：
2021-08-05
影响因子：
3.2
作者：
McKenna, Kristin R.;Clowers, Brian H.;Fernandez, Facundo M.
通讯作者：
Fernandez, Facundo M.