Immune and inflammatory response in pigs during acute influenza caused by H1N1 swine influenza virus.
Immune and inflammatory response in pigs during acute influenza caused by H1N1 swine influenza virus.
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H1N1 猪流感病毒引起的急性流感期间猪的免疫和炎症反应。
DOI：
10.1007/s00705-014-2116-1
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发表时间：
2014-10
影响因子：
2.7
通讯作者：
Pejsak, Zygmunt
中科院分区：
文献类型：
--
作者：
Pomorska-Mol, Magorzata;Markowska-Daniel, Iwona;Kwit, Krzysztof;Czyzewska, Ewelina;Dors, Arkadiusz;Rachubik, Jaroslaw;Pejsak, Zygmunt
猪流感(SI)是由猪流感病毒(SIV)引起的猪的一种急性呼吸道疾病。关于急性SI时肺部的炎症反应及其与临床体征或肺病理的关系，人们知之甚少。此外，到目前为止，关于SIV感染猪肺内促炎和抗炎细胞因子浓度与血清急性时相蛋白(APP)浓度之间的关系的数据有限。本研究对H1N1亚型流感病毒(SwH1N1)引起的猪急性流感期间的炎症反应和免疫反应进行了研究。9头猪经气管内感染，5头作为对照。用血凝抑制试验检测SIV抗体，用增殖试验检测流感病毒特异性T细胞应答。血清中C反应蛋白、结合珠蛋白、血清淀粉样蛋白A和猪主要急性时相蛋白(PIG-MAP)的浓度和肺组织中IL-1β、IL-6、IL-8、IL-10、肿瘤坏死因子-α和干扰素-γ的浓度采用商品化ELISA法测定。
Swine influenza (SI) is an acute respiratory disease of pigs, caused by swine influenza virus (SIV). Little is known about the inflammatory response in the lung during acute SI and its correlation with clinical signs or lung pathology. Moreover, until now there has been a limited amount of data available on the relationship between the concentrations of pro- and anti-inflammatory cytokines in the lungs and the serum concentration of acute-phase proteins (APPs) in SIV-infected pigs. In the present study, the porcine inflammatory and immune responses during acute influenza caused by H1N1 SIV (SwH1N1) were studied. Nine pigs were infected intratracheally, and five served as controls. Antibodies against SIV were measured by haemagglutination inhibition assay, and the influenza-virus-specific T-cell response was measured using a proliferation assay. C-reactive protein (CRP), haptoglobin (Hp), serum amyloid A (SAA), and pig major acute-phase protein (Pig-MAP) the concentrations in serum and concentration of IL-1β, IL-6, IL-8, IL-10, TNF-α and IFN-γ in lung tissues were measured using commercial ELISAs.
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影响因子：
--
作者：
Pomorska-Mol, Malgorzata;Markowska-Daniel, Iwona;Kwit, Krzysztof
通讯作者：
Kwit, Krzysztof
影响因子：
3.7
作者：
Brookes SM;Núñez A;Choudhury B;Matrosovich M;Essen SC;Clifford D;Slomka MJ;Kuntz-Simon G;Garcon F;Nash B;Hanna A;Heegaard PM;Quéguiner S;Chiapponi C;Bublot M;Garcia JM;Gardner R;Foni E;Loeffen W;Larsen L;Van Reeth K;Banks J;Irvine RM;Brown IH
通讯作者：
Brown IH
DOI：
10.1111/j.1439-0450.2006.01002.x
发表时间：
2006-12-01
期刊：
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH
影响因子：
--
作者：
Parra, M. D.;Fuentes, P.;Ceron, J. J.
通讯作者：
Ceron, J. J.
影响因子：
4.4
作者：
Slomka MJ;Densham AL;Coward VJ;Essen S;Brookes SM;Irvine RM;Spackman E;Ridgeon J;Gardner R;Hanna A;Suarez DL;Brown IH
通讯作者：
Brown IH
影响因子：
6.4
作者：
Van Reeth, K;Nauwynck, H;Pensaert, M
通讯作者：
Pensaert, M