Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum.
Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum.
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DOI：
10.1093/schbul/sbac007
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发表时间：
2022-05-07
影响因子：
6.6
通讯作者：
Sommer, Iris E. C.
中科院分区：
文献类型：
--
作者：
Schutte, Maya J. L.;Voppel, Alban;Collin, Guusje;Abramovic, Lucija;Boks, Marco P. M.;Cahn, Wiepke;van Haren, Neeltje E. M.;Hugdahl, Kenneth;Koops, Sanne;Mandl, Rene C. W.;Sommer, Iris E. C.
包括模块化网络组织在内的功能性连接体改变与幻觉体验有关。在精神病连续体中出现幻觉的个体是否在模块化大脑网络组织中表现出类似的变化仍有待确定。本研究评估了465名有和没有幻觉的个体的功能连接矩阵，包括精神分裂症和双相情感障碍患者、有幻觉的非临床个体和健康对照者。模块化大脑网络组织在不同的网络分辨率尺度上进行了研究，包括(1)以Qmax和规范化互信息（NMI）分数衡量的全球模块化，以及(2)模块内和模块间的连通性。全球模块化组织在各组之间没有显著改变。然而，与对照组相比，在精神分裂症患者和有幻觉的非临床个体中，高阶认知（例如，中央执行显著性、记忆、默认模式）和感觉模块中，模块内部和模块之间的连通性发生了变化。与对照组相比，双相情感障碍患者的幻觉在模块内和模块之间的连接模式发生了不同的改变，包括视觉、默认模式和记忆网络，而视觉、显著性和认知控制模块之间的连接模式没有改变。没有幻觉的双相情感障碍患者与对照组相比没有明显的变化。这项研究为有幻觉倾向的个体的功能连接体模块组织的改变提供了证据，精神分裂症患者和非临床个体在感觉和高阶认知模块上表现出类似的改变。其他高阶认知模块被发现与双相情感障碍患者的幻觉有关，这表明不同的神经机制可能是精神病连续体幻觉的基础。
Functional connectome alterations, including modular network organization, have been related to the experience of hallucinations. It remains to be determined whether individuals with hallucinations across the psychosis continuum exhibit similar alterations in modular brain network organization. This study assessed functional connectivity matrices of 465 individuals with and without hallucinations, including patients with schizophrenia and bipolar disorder, nonclinical individuals with hallucinations, and healthy controls. Modular brain network organization was examined at different scales of network resolution, including (1) global modularity measured as Qmax and Normalised Mutual Information (NMI) scores, and (2) within- and between-module connectivity. Global modular organization was not significantly altered across groups. However, alterations in within- and between-module connectivity were observed for higher-order cognitive (e.g., central-executive salience, memory, default mode), and sensory modules in patients with schizophrenia and nonclinical individuals with hallucinations relative to controls. Dissimilar patterns of altered within- and between-module connectivity were found bipolar disorder patients with hallucinations relative to controls, including the visual, default mode, and memory network, while connectivity patterns between visual, salience, and cognitive control modules were unaltered. Bipolar disorder patients without hallucinations did not show significant alterations relative to controls. This study provides evidence for alterations in the modular organization of the functional connectome in individuals prone to hallucinations, with schizophrenia patients and nonclinical individuals showing similar alterations in sensory and higher-order cognitive modules. Other higher-order cognitive modules were found to relate to hallucinations in bipolar disorder patients, suggesting differential neural mechanisms may underlie hallucinations across the psychosis continuum.
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影响因子：
6.6
作者：
Alderson-Day B;Diederen K;Fernyhough C;Ford JM;Horga G;Margulies DS;McCarthy-Jones S;Northoff G;Shine JM;Turner J;van de Ven V;van Lutterveld R;Waters F;Jardri R
通讯作者：
Jardri R
影响因子：
6.6
作者：
Allen, Paul;Modinos, Gemma;Hoffman, Ralph
通讯作者：
Hoffman, Ralph
DOI：
10.1088/1742-5468/2005/09/p09008
发表时间：
2005-09-01
影响因子：
2.4
作者：
Danon, L;Díaz-Guilera, A;Arenas, A
通讯作者：
Arenas, A
影响因子：
17.7
作者：
Diederen, Kelly M. J.;Neggers, Sebastiaan F. W.;Sommer, Iris E. C.
通讯作者：
Sommer, Iris E. C.
影响因子：
4.8
作者：
Collin G;van den Heuvel MP;Abramovic L;Vreeker A;de Reus MA;van Haren NE;Boks MP;Ophoff RA;Kahn RS
通讯作者：
Kahn RS