Co-infection of human papillomavirus and other sexually transmitted bacteria in cervical cancer patients in the Philippines.
Co-infection of human papillomavirus and other sexually transmitted bacteria in cervical cancer patients in the Philippines.
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DOI：
10.1016/j.gore.2022.100943
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发表时间：
2022-04
影响因子：
1.2
通讯作者：
Yanagihara I
中科院分区：
文献类型：
--
作者：
Tantengco OAG;Nakura Y;Yoshimura M;Nishiumi F;Llamas-Clark EF;Yanagihara I
HPV 16/18/33/52在菲律宾宫颈癌患者中的患病率为75%。HPV 16/18/33/52感染与宫颈癌显著相关（OR：9.00; 95%CI：2.18-37.18）。HPV-16是菲律宾宫颈癌患者中最常见的HPV基因型。HPV-18和HPV-52仅在宫颈癌患者中检测到。在HPV阳性的患者中，我们注意到22.73%的合并感染与支原体属。支原体感染率为9.09%。宫颈癌是全球女性第四大常见癌症。根据几项流行病学研究，人乳头瘤病毒与宫颈肿瘤密切相关。除HPV外，生殖道中的其他细菌感染与宫颈肿瘤有关。本研究旨在确定HPV感染的患病率;以及与脲原体属的合并感染，支原体属，菲律宾宫颈癌患者中的沙眼衣原体和淋病奈瑟菌。本研究纳入了2016年至2017年在菲律宾总医院就诊的44例患者（28例宫颈癌患者和16例非恶性宫颈患者）。解脲支原体属HPV基因分型及基因检测，支原体属，C. trachomatis和N.使用不同的PCR测定进行淋病。HPV 16/18/33/52的患病率在宫颈癌患者中为75%，在对照患者中为25%。HPV 16/18/33/52感染与宫颈癌显著相关（OR：9.00; 95% CI：2.18-37.18; p = 0.0024）。HPV-16是菲律宾宫颈癌患者中最常见的HPV基因型。HPV-18和HPV-52仅在宫颈癌患者中检测到。在HPV阳性的患者中，我们注意到22.73%的合并感染与支原体属。支原体混合感染率为9.09%。据我们所知，这是第一项关于菲律宾宫颈癌患者中HPV和性传播感染合并感染的研究。
The prevalence of HPV 16/18/33/52 was 75% in Filipino cervical cancer patients. Infection with HPV 16/18/33/52 was significantly associated with cervical cancer (OR: 9.00; 95% CI: 2.18–37.18). HPV-16 was the most prevalent HPV genotype among Filipino cervical cancer patients. HPV-18 and HPV-52 were only detected from cervical cancer patients. Among HPV-positive patients, we noted a 22.73% co-infection with Ureaplasma spp. and 9.09% with Mycoplasma spp. Cervical cancer is the fourth most common cancer in women globally. Based on several epidemiologic studies, human papillomavirus is strongly associated with cervical neoplasia. Aside from HPV, other bacterial infections in the genital tract were associated with cervical neoplasia. This study aimed to determine the prevalence of HPV infection; and co-infection with Ureaplasma spp., Mycoplasma spp., Chlamydia trachomatis, and Neisseria gonorrheae in Filipino cervical cancer patients. Forty-four patients (28 patients with cervical carcinoma and 16 patients with non-malignant cervix) who consulted in the Philippine General Hospital from 2016 to 2017 were included in this study. HPV genotyping and genetic detection of Ureaplasma spp., Mycoplasma spp., C. trachomatis, and N. gonorrheae were done using different PCR assays. The prevalence of HPV 16/18/33/52 was 75% in cervical cancer patients and 25% in control patients. Infection with HPV 16/18/33/52 was significantly associated with having cervical cancer (OR: 9.00; 95% CI: 2.18–37.18; p = 0.0024). HPV-16 was the most prevalent HPV genotype among Filipino cervical cancer patients. HPV-18 and HPV-52 were only detected from cervical cancer patients. Among HPV-positive patients, we noted a 22.73% co-infection with Ureaplasma spp. and 9.09% co-infection with Mycoplasma spp. To our knowledge, this is the first study on the co-infection of HPV and sexually transmitted infections among cervical cancer patients in the Philippines.
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影响因子：
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作者：
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通讯作者：
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DOI：
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