Co-infection Of Ureaplasma urealyticum And Human Papilloma Virus In Asymptomatic Sexually Active Individuals.
Co-infection Of Ureaplasma urealyticum And Human Papilloma Virus In Asymptomatic Sexually Active Individuals.
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DOI：
10.7150/ijms.26523
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发表时间：
2018
影响因子：
3.6
通讯作者：
Lee SJ
中科院分区：
文献类型：
--
作者：
Kim SI;Yoon JH;Park DC;Lee DS;Lee SJ;Choe HS;Kim JH;Park TC;Lee SJ
本研究旨在确定无症状性细菌性性传播感染（STI），如沙眼衣原体（Ct），生殖支原体（Mg），人型支原体（Mh）和解脲支原体（Uu）在人乳头瘤病毒（HPV）感染中的作用。共有264例年龄在21至80岁之间的无症状门诊患者在常规妇科筛查试验期间前瞻性入组本研究。使用Hybrid Capture 2检测试剂盒对用Cervex刷采集的标本进行常规HPV分析。同时，用宫颈拭子获得的标本用于用单重实时聚合酶链反应（PCR）检测Ct和Mg，并用支原体IST 2试剂盒确认Mh和Uu。HPV、Ct、Mg、Mh和Uu的检出率分别为82/264（31.1）、6/264（2.3）、5/264（1.9）、16/264（6.1）和95/264（36.0）。在95株Uu中，32株（33.7%）表现为高密度定植（HDC，≥104变色单位/mL）。HDC-Uu与HPV感染显著相关（p=0.014，卡方检验）。Mg感染和Mh感染与HPV感染无关（p=0.981和p=0.931，卡方检验）。年龄与HPV感染或细菌感染无关。提示无症状HDC-Uu与HPV感染密切相关。因此，在妇科筛查中应同时进行Uu和HPV的评估，即使是在无症状的个体中。
This study aimed to determine the role of asymptomatic bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (Ct), Mycoplasma genitalium (Mg), Mycoplasma hominis (Mh), and Ureaplasma urealyticum (Uu) in human papillomavirus (HPV) infection. In total, 264 asymptomatic outpatients aged between 21 and 80 years were prospectively enrolled in this study during routine gynecological screening tests. Specimens collected with a Cervex Brush were routinely analyzed with the Hybrid Capture 2 assay for HPV. Simultaneously, a specimen obtained with an endocervical swab was used to detect Ct and Mg with a monoplex real-time polymerase chain reaction (PCR) and to confirm Mh and Uu with a Mycoplasma IST 2 kit. The detection rates (%) of HPV, Ct, Mg, Mh, and Uu were 82/264 (31.1), 6/264 (2.3), 5/264 (1.9), 16/264 (6.1), and 95/264 (36.0), respectively. Of 95 Uu, 32 (33.7%) showed high density colonization (HDC, ≥104 color-changing units/mL). HDC-Uu was significantly associated with HPV infection (p=0.014, chi-square test). Mg infection and Mh infection were not associated with HPV infection (p=0.981 and p=0.931, chi-square test). Age was not associated with HPV infection or bacterial infection. Our data suggested that asymptomatic HDC-Uu was closely associated with HPV infection. Therefore, simultaneous evaluation for Uu and HPV should be performed during gynecological screening, even in asymptomatic individuals.
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影响因子：
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