A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing.
A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing.
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DOI：
10.1126/sciadv.abl8379
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发表时间：
2022-01-28
期刊：
影响因子：
13.6
通讯作者：
Lin Y
中科院分区：
文献类型：
--
作者：
Yao G;Mo X;Yin C;Lou W;Wang Q;Huang S;Mao L;Chen S;Zhao K;Pan T;Huang L;Lin Y
机械调节和电刺激在皮肤组织工程中用于操纵伤口愈合具有很大的前景。然而，设备操作和刺激实施的复杂性仍然是临床应用中的持续挑战。在这里，我们提出了一种可编程和皮肤温度激活的机电协同伤口敷料组成的形状记忆合金为基础的机械超材料的伤口收缩和抗菌驻极体薄膜的电场产生。该策略在大鼠上成功地证明了线性和圆形伤口分别在短至4天和8天内实现有效的伤口愈合，与空白对照组相比，伤口闭合率在统计学上显著改善超过50%。优化设计的机电协同刺激可以调节伤口微环境，加速愈合代谢，促进伤口闭合，抑制感染。这项工作提供了一个有效的伤口愈合策略的背景下，可编程的温度响应，无电池的机电协同生物医学设备。智能机电协同敷料治疗不同形状的伤口。
Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature–activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optimally designed electromechanical synergistic stimulation could regulate the wound microenvironment to accelerate healing metabolism, promote wound closure, and inhibit infection. This work provided an effective wound healing strategy in the context of a programmable temperature-responsive, battery-free electromechanical synergistic biomedical device. Smart electromechanical synergistic dressings treat wounds of different shapes.
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影响因子：
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作者：
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