Molecular imaging for cancer diagnosis and surgery.
Molecular imaging for cancer diagnosis and surgery.
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DOI：
10.1016/j.addr.2013.09.007
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发表时间：
2014-02
影响因子：
16.1
通讯作者：
Nguyen, Quyen T.
中科院分区：
文献类型：
--
作者：
Hussain, Timon;Nguyen, Quyen T.
新的分子成像技术有可能显着提高癌症的诊断和治疗方法。特别是对于实体瘤，用于成像方式如US、CT、MRI和PET的新型分子增强剂可以促进更早和更准确的诊断和分期，这是成功手术治疗的先决条件。酶可激活的“智能”分子MRI探针似乎特别有前途，因为它们有可能在手术切除之前和之后对肿瘤进行成像，而无需重新施用探针以评估手术切除的完整性。此外，使用“智能”MR探针作为筛查程序的一部分，可以在高危患者人群中检测全身的小肿瘤。用荧光染料对分子MR探针进行双重标记可以增加真实的时间术中指导，从而促进完整的肿瘤切除和重要结构的保留。一个真正的治疗诊断方法，进一步添加治疗剂的分子探针辅助治疗是可以想象的未来。
Novel molecular imaging techniques have the potential to significantly enhance the diagnostic and therapeutic approaches for cancer treatment. For solid tumors in particular, novel molecular enhancers for imaging modalities such as US, CT, MRI and PET may facilitate earlier and more accurate diagnosis and staging which are prerequisites for successful surgical therapy. Enzymatically activatable “smart” molecular MRI probes seem particularly promising because of their potential to image tumors before and after surgical removal without re-administration of the probe to evaluate completeness of surgical resection. Furthermore, the use of “smart” MR probes as part of screening programs may enable detection of small tumors throughout the body in at-risk patient populations. Dual labeling of molecular MR probes with fluorescent dyes can add real time intraoperative guidance facilitating complete tumor resection and preservation of important structures. A truly theranostic approach with the further addition of therapeutic agents to the molecular probe for adjuvant therapy is conceivable for the future.
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影响因子：
--
作者：
Tran Cao HS;Kaushal S;Metildi CA;Menen RS;Lee C;Snyder CS;Messer K;Pu M;Luiken GA;Talamini MA;Hoffman RM;Bouvet M
通讯作者：
Bouvet M
影响因子：
37.8
作者：
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通讯作者：
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影响因子：
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影响因子：
3.3
作者：
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通讯作者：
Conolly, SM