Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya.
Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya.
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DOI：
10.1371/journal.pone.0057513
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zimmermann MB
中科院分区：
文献类型：
--
作者：
Jaeggi T;Moretti D;Kvalsvig J;Holding PA;Tjalsma H;Kortman GA;Joosten I;Mwangi A;Zimmermann MB
在婴儿中还没有研究过通过竞争性刺激如感染和铁缺乏对铁调素的调节，并且还不知道铁调素调节途径是否在婴儿中完全起作用。在这项横断面研究中，包括339名年龄为6.0±1.1个月（平均值±SD）的肯尼亚婴儿，我们评估了血清铁调素-25，铁状态和炎症的生物标志物，以及粪便钙卫蛋白。炎症、贫血、铁缺乏的患病率分别为31%、71%、26%。血清铁调素的几何平均值（±SD）为6.0（±3.4）ng/mL，男性显著低于女性。炎症（C-反应蛋白和白细胞介素-6）和铁状态（血清铁蛋白，锌原卟啉和可溶性转铁蛋白受体）是血清铁调素的重要预测因子，解释了近60%的变异。无炎症的缺铁性贫血（IDA）婴儿与有炎症的缺铁性贫血婴儿相比，血清铁调素水平差异较小，但具有显著性（1.2（±4.9）ng/mL vs. 3.4（±4.9）ng/mL; P<0.001）。粪便钙卫蛋白与粪便中的血液/粘液相关，但与铁调素无关。类似地，肠道连接的细胞因子IL-12和IL-17与铁调素无关。我们的结论是，铁调素调节途径已经在婴儿期的功能，但血清铁调素单独可能无法明确区分缺铁性贫血的婴儿感染和不感染。我们提出了无炎症的铁充足婴儿血清铁调素的性别特异性参考值。
Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it’s yet unknown whether hepcidin regulatory pathways are fully functional in infants. In this cross-sectional study including 339 Kenyan infants aged 6.0±1.1 months (mean±SD), we assessed serum hepcidin-25, biomarkers of iron status and inflammation, and fecal calprotectin. Prevalence of inflammation, anemia, and iron deficiency was 31%, 71%, 26%, respectively. Geometric mean (±SD) serum hepcidin was 6.0 (±3.4) ng/mL, and was significantly lower in males than females. Inflammation (C-reactive protein and interleukin-6) and iron status (serum ferritin, zinc protoporphyrin and soluble transferrin receptor) were significant predictors of serum hepcidin, explaining nearly 60% of its variance. There were small, but significant differences in serum hepcidin comparing iron deficient anemic (IDA) infants without inflammation to iron-deficient anemic infants with inflammation (1.2 (±4.9) vs. 3.4 (±4.9) ng/mL; P<0.001). Fecal calprotectin correlated with blood/mucus in the stool but not with hepcidin. Similarly, the gut-linked cytokines IL-12 and IL-17 did not correlate with hepcidin. We conclude that hepcidin regulatory pathways are already functional in infancy, but serum hepcidin alone may not clearly discriminate between iron-deficient anemic infants with and without infection. We propose gender-specific reference values for serum hepcidin in iron-replete infants without inflammation.
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