Evolutionary Biology of Pathogenic Enterococci
Evolutionary Biology of Pathogenic Enterococci
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致病性肠球菌的进化生物学
DOI：
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
T. Coque
中科院分区：
文献类型：
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作者：
T. Coque
本章重点介绍可能导致肠球菌作为人类病原体的性质和生态特征。对宿主-病原体相互作用的分子基础的研究构成了生态基因组学这一新学科的基石，有望为疾病抑制提供见解。溶细胞素在不同来源的肠球菌中的广泛传播可能反映了对水或土壤中的肠球菌具有额外的抗真核活性。肠球菌是与大多数哺乳动物和鸟类相关的普遍存在的微生物，可从爬行动物、昆虫和自然环境中恢复，显然没有暴露在严重的粪便污染中。侧向基因转移(LGT)似乎在粪肠球菌和粪肠球菌的进化及其对特定环境的适应中起着关键作用。此外，在现有测序基因组中发现的移动性和外源成分的多样性可能解释了肠球菌基因组与任何测序的低GC生物之间缺乏同步性的原因。关于元素和基因组的转移和序列的日益增长的知识揭示了细菌适应的多种策略。一节总结了在肠球菌中发现的可移动遗传元件(MGE)的现有知识，以及它们在属于同一交换社区的其他微生物中的分布。粪肠球菌PAI基因全长154kb，编码广为人知的肠球菌毒力特征。1/3的致病岛(PAI)由肠球菌信息素应答质粒PAD1和PAM373的结构基因组成，这表明该PAI的进化建立在质粒整合事件的基础上。
This chapter focuses on the properties and ecological features that might contribute to enterococci behaving as a human pathogen. The study of the molecular bases of the host-pathogen interactions constitutes the cornerstone of the new discipline of ecogenomics that is expected to provide insights for disease suppression. The wide dissemination of cytolysin in enterococci from different origins might reflect the selection of additional antieukaryotic activities for enterococci in water or soil niches. Enterococci are ubiquitous microorganisms associated with most mammals and birds and are recovered from reptiles, insects, and natural environments apparently lacking exposure to heavy fecal contamination. Lateral gene transfer (LGT) seems to play a critical role in the evolution of Enterococcus faecalis and E. faecium and their adaptation to specific environments. In addition, the multiplicity of mobile and foreign elements found in available sequenced genomes might explain the lack of synteny between genomes of enterococci and any sequenced low-GC organisms. The growing knowledge about transfer and sequences of elements and genomes has revealed a multitude of strategies for bacterial adaptation. A section summarizes the available knowledge on mobile genetic elements (MGE) found among enterococci and their distribution among other microorganisms belonging to the same exchange communities. The 154-kb E. faecalis PAI encodes well-known putative enterococcal virulence traits. One-third of the pathogenicity island (PAI) consists of structural genes from the enterococcal pheromone-responsive plasmids pAD1 and pAM373, indicating that the evolutionary building-up of this PAI was based on plasmid-integration events.
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影响因子：
2.1
作者：
K. Ojo;D. Tung;H. Luís;M. Bernardo;J. Leitão;M. Roberts
通讯作者：
K. Ojo;D. Tung;H. Luís;M. Bernardo;J. Leitão;M. Roberts
影响因子：
--
作者：
J. M. Rivas;P. Speziale;J. Patti;M. Höök
通讯作者：
J. M. Rivas;P. Speziale;J. Patti;M. Höök
影响因子：
6.4
作者：
Rice, LB;Carias, L;Murray, BE
通讯作者：
Murray, BE
影响因子：
15.9
作者：
Nallapareddy, Sreedhar R.;Singh, Kavindra V.;Murray, Barbara E.
通讯作者：
Murray, Barbara E.