Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction.
Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction.
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DOI：
10.3390/ijms22073312
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发表时间：
2021-03-24
影响因子：
5.6
通讯作者：
MacNicol AM
中科院分区：
文献类型：
--
作者：
Odle AK;MacNicol MC;Childs GV;MacNicol AM
垂体促性腺激素释放激素受体（GnRHRs）的正确表达对维持最大生殖能力至关重要。GnRH受体的表达必须严格调节，以维持正常的表达模式，通过在啮齿动物的发情周期，这被认为是重要的解释微调脉冲的GnRH从下丘脑。许多研究表明，Gnrhr的表达在转录水平上受到高度调控。然而，研究人员还发现Gnrhr是转录后调节的。本文将讨论如何RNA结合蛋白和microRNA可能发挥关键作用的GnRHR表达的调节。我们还将讨论这些转录后调节因子本身如何受到代谢线索的影响，特别是脂肪因子瘦素。总之，我们提出的证据表明，Gnrhr的转录后调节，这一概念必须进一步探讨，以充分了解这种受体的复杂性。
The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern of expression through the estrous cycle in rodents, which is believed to be important for interpreting the finely tuned pulses of GnRH from the hypothalamus. Much work has shown that Gnrhr expression is heavily regulated at the level of transcription. However, researchers have also discovered that Gnrhr is regulated post-transcriptionally. This review will discuss how RNA-binding proteins and microRNAs may play critical roles in the regulation of GnRHR expression. We will also discuss how these post-transcriptional regulators may themselves be affected by metabolic cues, specifically with regards to the adipokine leptin. All together, we present evidence that Gnrhr is regulated post-transcriptionally, and that this concept must be further explored in order to fully understand the complex nature of this receptor.
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影响因子：
3.2
作者：
Allensworth-James ML;Odle AK;Lim J;LaGasse AN;Miles TK;Hardy LL;Haney AC;MacNicol MC;MacNicol AM;Childs GV
通讯作者：
Childs GV
影响因子：
56.9
作者：
Chehab, FF;Mounzih, K;Lim, ME
通讯作者：
Lim, ME
影响因子：
56.9
作者：
BELCHETZ, PE;PLANT, TM;KNOBIL, E
通讯作者：
KNOBIL, E
影响因子：
15.9
作者：
Ahmed, Kashan;LaPierre, Mary P.;Stoffel, Markus
通讯作者：
Stoffel, Markus
影响因子：
4.8
作者：
Barash, IA;Cheung, CC;Steiner, RA
通讯作者：
Steiner, RA