Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance.
Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance.
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DOI：
10.1016/j.cell.2011.11.041
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发表时间：
2011-12-23
期刊：
影响因子：
64.5
通讯作者：
Banerjee U
中科院分区：
文献类型：
--
作者：
Mondal BC;Mukherjee T;Mandal L;Evans CJ;Sinenko SA;Martinez-Agosto JA;Banerjee U
维持造血祖细胞群需要与微环境或生态位内的细胞进行广泛的相互作用。在果蝇的造血器官中，小生境衍生的Hedgehog信号传导维持着祖细胞的数量。在这里，我们发现造血祖细胞也需要一个由腺苷脱氨酶生长因子a （Adgf-A）介导的信号，该信号来自于调节胞外腺苷水平的分化细胞。在造血祖细胞内，腺苷信号与Hedgehog信号的作用相反，腺苷信号的大小由分化细胞分泌的Adgf-A水平来控制。我们的研究结果揭示了分化细胞产生的信号是维持祖细胞静止所必需的，并且与小生境来源的信号一起作用于维持祖细胞状态。类似的内稳态机制可能在其他系统中被利用，这些系统维持相对大量的祖细胞，这些祖细胞并不都与生态位的细胞直接接触。
Maintenance of a hematopoietic progenitor population requires extensive interaction with cells within a microenvironment or niche. In the Drosophila hematopoietic organ, niche-derived Hedgehog signaling maintains the progenitor population. Here we show that the hematopoietic progenitors also require a signal mediated by Adenosine deaminase growth factor A (Adgf-A) arising from differentiating cells that regulates extracellular levels of adenosine. The adenosine signal opposes the effects of Hedgehog signaling within the hematopoietic progenitor cells and the magnitude of the adenosine signal is kept in check by the level of Adgf-A secreted from differentiating cells. Our findings reveal signals arising from differentiating cells that are required for maintaining progenitor cell quiescence, and that function with the niche-derived signal in maintaining the progenitor state. Similar homeostatic mechanisms are likely to be utilized in other systems that maintain relatively large numbers of progenitors that are not all in direct contact with the cells of the niche.
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影响因子：
9.8
作者：
Crozatier M;Ubeda JM;Vincent A;Meister M
通讯作者：
Meister M
DOI：
10.1126/science.1180794
发表时间：
2010-01-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li L;Clevers H
通讯作者：
Clevers H
影响因子：
64.5
作者：
Hsu YC;Pasolli HA;Fuchs E
通讯作者：
Fuchs E
影响因子：
3.3
作者：
Giansanti, MG;Farkas, RM;Gatti, M
通讯作者：
Gatti, M
影响因子：
3.8
作者：
Dolezelova, Eva;Nothacker, Hans-Peter;Zurovec, Michal
通讯作者：
Zurovec, Michal