Cysteine-activated hydrogen sulfide (H2S) donors.

Cysteine-activated hydrogen sulfide (H2S) donors.
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DOI:
10.1021/ja1085723
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发表时间:
2011-01-12
影响因子:
15
通讯作者:
Xian, Ming
Xian, Ming
中科院分区:
化学1区
文献类型:
--
作者:
Zhao, Yu;Wang, Hua;Xian, Ming

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H_2S是一种新发现的气体递质,在生物系统中起着重要的作用。然而,由于缺乏能够模拟体内缓慢而连续的H2S生成过程的可控H2S供体,阻碍了H2S的研究。在这里,我们报告了一系列的半胱氨酸激活的H2S供体。对这些分子的结构修饰可以调节H2S生成速率。这些化合物可以在H2S研究中成为有用的工具。
H2S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H2S has been hindered by lacking controllable H2S donors which could mimic the slow and continuous H2S generation process in vivo. Herein we report a series of cysteine-activated H2S donors. Structural modifications on these molecules can regulate the rates of H2S generation. These compounds can be useful tools in H2S research.
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