Do antibiotic residues in soils play a role in amplification and transmission of antibiotic resistant bacteria in cattle populations?
Do antibiotic residues in soils play a role in amplification and transmission of antibiotic resistant bacteria in cattle populations?
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DOI：
10.3389/fmicb.2013.00193
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发表时间：
2013
影响因子：
5.2
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Call DR;Matthews L;Subbiah M;Liu J
当我们考虑导致抗生素耐药菌出现、扩增和持续存在的因素时，传统的假设是抗生素的使用是这些过程的主要驱动力，选择主要发生在患者或动物身上。有证据表明，情况并非总是如此。实验性试验表明，在牛中胃肠外给予第三代头孢菌素（头孢噻呋）对胃肠道中头孢噻呋耐药细菌的流行率具有有限或短期影响。虽然这种反应可能足以解释头孢菌素类的广泛耐药模式，但约三分之二的头孢噻呋代谢产物经尿液排泄，这增加了环境选择在抗生素耐药大肠埃希菌的扩增和维持中发挥重要叠加作用的可能性。农场里的大肠杆菌因此，我们提出了环境选择假说的基本原理，即排泄的抗生素残留物（如头孢噻呋）是食品动物系统中抗生素耐药菌增殖的重要因素。我们还提出了一个数学模型，我们假设的系统作为指导设计实验来测试这一假设。如果支持头孢噻呋等抗生素，那么可能会有新的方法来对抗抗生素耐药性的扩散，而不仅仅是谨慎使用的咒语。
When we consider factors that contribute to the emergence, amplification, and persistence of antibiotic resistant bacteria, the conventional assumption is that antibiotic use is the primary driver in these processes and that selection occurs primarily in the patient or animal. Evidence suggests that this may not always be the case. Experimental trials show that parenteral administration of a third-generation cephalosporin (ceftiofur) in cattle has limited or short-term effects on the prevalence of ceftiofur-resistant bacteria in the gastrointestinal tract. While this response may be sufficient to explain a pattern of widespread resistance to cephalosporins, approximately two-thirds of ceftiofur metabolites are excreted in the urine raising the possibility that environmental selection plays an important additive role in the amplification and maintenance of antibiotic resistant E. coli on farms. Consequently, we present a rationale for an environmental selection hypothesis whereby excreted antibiotic residues such as ceftiofur are a significant contributor to the proliferation of antibiotic resistant bacteria in food animal systems. We also present a mathematical model of our hypothesized system as a guide for designing experiments to test this hypothesis. If supported for antibiotics such as ceftiofur, then there may be new approaches to combat the proliferation of antibiotic resistance beyond the prudent use mantra.
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影响因子：
1
作者：
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通讯作者：
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DOI：
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发表时间：
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