Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis.
Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis.
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DOI：
10.1016/j.fertnstert.2012.02.007
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发表时间：
2012-05
影响因子：
6.7
通讯作者：
Tekmal, Rajeshwar Rao
中科院分区：
文献类型：
--
作者：
Budrys, Nicole M.;Nair, Hareesh B.;Liu, Ya-Guang;Kirma, Nameer B.;Binkley, Peter A.;Kumar, Shantha;Schenken, Robert S.;Tekmal, Rajeshwar Rao
关键词：
To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis. In vivo and vitro study. University-based academic medical center. Reproductive-age women undergoing surgery for benign conditions. Peritoneal and endometrial tissue samples were obtained. CSF-1 and C-FMS expression. Significantly higher CSF-1 levels were found in peritoneal fluid of patients with endometriosis compared with control subjects. Ectopic endometriotic tissue had 3.5-fold and 1.7-fold increases in CSF-1 and C-FMS expression, respectively, compared with eutopic tissue. Coculture of endometrial cells from either established cell lines or patient samples with peritoneal mesothelial cells (PMCs) led to increased expression of CSF-1 and C-FMS. A higher but nonsignificant increase in levels of C-FMS and CSF-1 was found in cocultures of endometrial epithelial cells from patients with endometriosis compared with those without endometriosis. Increased CSF-1 levels may contribute to endometriosis lesion formation and progression. Elevation in CSF-1 after coculture of endometrial cells with PMCs suggests that endometrial tissue may be a source of peritoneal CSF-1. Increased C-FMS expression in endometrial cells from women with endometriosis cocultured with PMCs suggests that endometrial tissue involved in lesion formation is highly responsive to CSF-1 signaling. (Fertil Steril® 2012;97:1129-35. ©2012 by American Society for Reproductive Medicine.)
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DOI：
10.1177/1933719108330568
发表时间：
2009-04
期刊：
Reproductive sciences (Thousand Oaks, Calif.)
影响因子：
--
作者：
Rogers PA;D'Hooghe TM;Fazleabas A;Gargett CE;Giudice LC;Montgomery GW;Rombauts L;Salamonsen LA;Zondervan KT
通讯作者：
Zondervan KT
DOI：
10.1073/pnas.76.6.2969
发表时间：
1979-01-01
影响因子：
11.1
作者：
STANLEY, ER
通讯作者：
STANLEY, ER
DOI：
10.1016/s0889-8545(05)70302-8
发表时间：
1997-06-01
影响因子：
3.2
作者：
Eskenazi, B;Warner, ML
通讯作者：
Warner, ML
DOI：
10.1111/j.1600-0897.2004.00228.x
发表时间：
2004-11-01
影响因子：
3.6
作者：
Mettler, L;Schmutzler, AG;Salmassi, A
通讯作者：
Salmassi, A
影响因子：
6.7
作者：
Aligeti, Sabitha;Kirma, Nameer B.;Binkley, Peter A.;Schenken, Robert S.;Tekmal, Rajeshwar Rao
通讯作者：
Tekmal, Rajeshwar Rao