Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke.
Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke.
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DOI：
10.1016/j.nicl.2013.12.003
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发表时间：
2014
影响因子：
4.2
通讯作者：
Fukuyama, Hidenao
中科院分区：
文献类型：
--
作者：
Takenobu, Yohei;Hayashi, Takuya;Moriwaki, Hiroshi;Nagatsuka, Kazuyuki;Naritomi, Hiroaki;Fukuyama, Hidenao
关键词：
脑卒中后运动功能恢复的机制可能涉及存活网络的重组。然而，结构连接性的自适应变化的细节还没有得到很好的理解。在这里，我们展示了与中风患者运动恢复相关的白色微结构的长期变化。我们研究了10名皮质下缺血性卒中患者，他们在初始临床检查时表现为运动性轻偏瘫，在初始弥散加权磁共振成像扫描时表现为单侧半球内囊后肢为中心的梗死病变。参与者在三个连续的时间点进行了连续的弥散张量成像和运动功能评估;在发病后2周内，以及1个月和3个月。分数各向异性（FA）半球和时间点之间的区域差异进行了分析，以及与运动恢复的相关性，使用基于轨迹的空间统计分析。结果显示：3个月时患侧红核和脑桥背侧FA显著增加，所有时间点患侧内囊FA显著减少，3个月时大脑脚、放射冠和胼胝体FA显著减少。相关性分析显示，红核、脑桥背侧、胼胝体中段、扣带回内的FA值与运动功能恢复呈正相关。我们的研究表明，白色微结构的变化，在替代下行运动束，包括红核脊髓通路，和纵裂胼胝体连接可能发挥关键作用，在补偿运动障碍后皮质下中风。皮质下卒中患者表现为运动性轻偏瘫，随后逐渐恢复。病变重叠部位以内囊后肢为中心。红核的各向异性分数（FA）在三个月内逐渐增加。红核FA与运动性轻瘫的恢复呈正相关。胼胝体中部的FA也与运动恢复有关。
The mechanism of motor recovery after stroke may involve reorganization of the surviving networks. However, details of adaptive changes in structural connectivity are not well understood. Here, we show long-term changes in white matter microstructure that relate to motor recovery in stroke patients. We studied ten subcortical ischemic stroke patients who showed motor hemiparesis at the initial clinical examination and an infarcted lesion centered in the posterior limb of internal capsule of the unilateral hemisphere at the initial diffusion-weighted magnetic resonance imaging scan. The participants underwent serial diffusion tensor imaging and motor function assessments at three consecutive time points; within 2 weeks, and at 1 and 3 months after the onset. Fractional anisotropy (FA) was analyzed for regional differences between hemispheres and time points, as well as for correlation with motor recovery using a tract-based spatial statistics analysis. The results showed significantly increased FA in the red nucleus and dorsal pons in the ipsi-lesional side at 3 months, and significantly decreased FA in the ipsi-lesional internal capsule at all time points, and in the cerebral peduncle, corona radiata, and corpus callosum at 3 months. In the correlation analysis, FA values of clusters in the red nucleus, dorsal pons, midbody of corpus callosum, and cingulum were positively correlated with recovery of motor function. Our study suggests that changes in white matter microstructure in alternative descending motor tracts including the rubro-spinal pathway, and interhemispheric callosal connections may play a key role in compensating for motor impairment after subcortical stroke. Subcortical stroke patients showed motor hemiparesis followed by gradual recovery. Lesion overlap was located with its center in the posterior limb of internal capsule. Fractional anisotropy (FA) gradually increased in the red nucleus in three months. FA in the red nucleus was positively correlated with recovery of motor paresis. FA in the middle part of corpus callosum was also correlated with motor recovery.
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影响因子：
15.1
作者：
Hayashi T;Shimazawa M;Watabe H;Ose T;Inokuchi Y;Ito Y;Yamanaka H;Urayama S;Watanabe Y;Hara H;Onoe H
通讯作者：
Onoe H
影响因子：
56.9
作者：
Nishimura, Yukio;Onoe, Hirotaka;Isa, Tadashi
通讯作者：
Isa, Tadashi
影响因子：
5.7
作者：
Johansen-Berg H;Della-Maggiore V;Behrens TE;Smith SM;Paus T
通讯作者：
Paus T
DOI：
10.1016/b978-0-12-374709-9.00006-7
发表时间：
2009-01-01
期刊：
DIFFUSION MRI: FROM QUANTITATIVE MEASUREMENT TO IN VIVO NEUROANATOMY
影响因子：
--
作者：
Beaulieu, Christian
通讯作者：
Beaulieu, Christian
影响因子：
2.9
作者：
Bradnam LV;Stinear CM;Byblow WD
通讯作者：
Byblow WD