Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.
Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0110569
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Chen YC
中科院分区：
文献类型：
--
作者：
Weng PH;Huang YL;Page JH;Chen JH;Xu J;Koutros S;Berndt S;Chanock S;Yeager M;Witte JS;Eeles RA;Easton DF;Neal DE;Donovan J;Hamdy FC;Muir KR;Giles G;Severi G;Smith JR;Balistreri CR;Shui IM;Chen YC
toll样受体4 （Toll-like receptor 4, TLR4）是在几种白细胞和组织细胞表面表达的TLR成员之一，在检测病原体和危险相关分子模式方面具有关键功能。TLR4在一些年龄相关疾病的病理生理中的作用也得到了很好的认识，如前列腺癌（PCa）。TLR4多态性与前列腺癌风险有关，但TLR4基因型与侵袭性前列腺癌风险之间的关系尚未得到任何系统评价。我们对候选基因和全基因组关联研究进行了系统回顾和荟萃分析，分析了这种关系，并且只包括白人人群。考虑到适当的标准，在荟萃分析中仅分析了9项研究，包括3,937例侵袭性PCa和7,382例对照。采用随机效应模型，在任意遗传模型（rs2737191、rs1927914、rs10759932、rs1927911、rs11536879、rs2149356、rs4986790、rs11536889、rs7873784和rs1554973）下，至少4项纳入的研究报告的10个TLR4 snp未发现显著关联。3项研究报告的另外10个TLR4 snp的汇总估计也显示无显著相关性（rs10759930、rs10116253、rs11536869、rs5030717、rs4986791、rs11536897、rs1927906、rs913930、rs1927905和rs7045953）。meta回归显示，研究类型不是研究间异质性的重要来源。TLR4多态性与侵袭性PCa的风险无显著相关。
Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews. We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls. Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity. TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.
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影响因子：
5.4
作者：
Dennis, LK;Dawson, DV
通讯作者：
Dawson, DV
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
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作者：
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通讯作者：
LAIRD, N
影响因子：
5.4
作者：
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通讯作者：
Imperiale, Michael J.
DOI：
10.1073/pnas.94.18.9669
发表时间：
1997-09-02
影响因子：
11.1
作者：
Cavallaro, S;Meiri, N;Alkon, DL
通讯作者：
Alkon, DL