Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence.
Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence.
复制标题
DOI：
10.1002/ijc.28003
复制
发表时间：
2013-09-01
影响因子：
6.4
通讯作者：
Correa, Pelayo
中科院分区：
文献类型：
--
作者：
Gonzalez, Carlos A.;Sanz-Anquela, Jose M.;Gisbert, Javier P.;Correa, Pelayo
对胃癌高危患者进行癌前病变的识别和监测是减轻胃癌负担的最有效方法。不完全型肠化生(IM)可作为监测的最佳对象。然而，IM亚型的有用性被一些作者认为是有限的和不一致的。进行搜索以确定所有评估不同类型IM受试者中GC风险的横断面研究(n=14)和后续研究(n=10)。在14项横断面研究中，13项报告称，胃癌不完全性肠化的患病率显著高于其他胃部病变。在十项后续研究中，有六项发现不完全IM与随后的GC风险之间存在统计学意义上的关联。在报告了风险大小的研究中，与完全型相比或与不存在不完全型相比，存在不完全类型的胃癌的相对风险高4-11倍。根据这篇综合综述，大多数科学证据支持IM亚型作为GC风险预测因子的效用。胃肠病学家认识到它的有效性，应该鼓励病理学家对IM进行分型。
The identification and surveillance of patients with preneoplastic lesions at high risk of progressing to gastric cancer (GC) represents the most effective way of reducing the burden of GC. The incomplete type of intestinal metaplasia (IM) could be considered as the best candidate for surveillance. However, the usefulness of subtyping of IM has been considered by some authors as limited and inconsistent. A search was carried out to identify all cross-sectional (n=14) and follow-up (n=10) studies that assessed the risk of GC among subjects with different types of IM. Out of the 14 cross-sectional studies, 13 reported that the prevalence of incomplete IM was statistically significantly higher in GC than in other gastric lesions. Out of the ten follow-up studies, six found a statistically significant association between incomplete IM and subsequent GC risk. The relative risks of GC were from 4- to 11-fold higher for the presence of incomplete type in comparison to complete type or in comparison to the absence of incomplete type, among the studies that reported the magnitude of the risk. According to this comprehensive review, most of the scientific evidence supports the utility of subtyping IM as a predictor of GC risk. Recognizing its usefulness by gastroenterologists should encourage pathologists to subtype IM.
登录
查看更多内容
影响因子：
24.5
作者：
FILIPE, MI;POTET, F;ZEEGEN, R
通讯作者：
ZEEGEN, R
影响因子：
9.8
作者：
Correa, Pelayo;Piazuelo, M. Blanca;Wilson, Keith T.
通讯作者：
Wilson, Keith T.
影响因子：
6.4
作者：
JASS, JR;FILIPE, MI
通讯作者：
FILIPE, MI
影响因子：
2.4
作者：
MATSUKURA, N;KAWACHI, T;KITAOKA, H
通讯作者：
KITAOKA, H
影响因子：
9.8
作者：
Cassaro, M;Rugge, M;Genta, RM
通讯作者：
Genta, RM