Prenatal and Early Childhood Exposure to Lead and Repeated Measures of Metabolic Syndrome Risk Indicators From Childhood to Preadolescence.
Prenatal and Early Childhood Exposure to Lead and Repeated Measures of Metabolic Syndrome Risk Indicators From Childhood to Preadolescence.
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DOI：
10.3389/fped.2021.750316
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发表时间：
2021
影响因子：
2.6
通讯作者：
Tamayo-Ortiz M
中科院分区：
文献类型：
--
作者：
Muciño-Sandoval K;Ariza AC;Ortiz-Panozo E;Pizano-Zárate ML;Mercado-García A;Wright R;Maria Téllez-Rojo M;Sanders AP;Tamayo-Ortiz M
背景：铅暴露与代谢综合征的发生有关。儿童关键发育窗口期铅暴露的纵向研究有限。研究方法：我们的研究包括来自PROGRESS（肥胖，生长，环境和社会压力的规划研究）出生队列的601对母子。在妊娠第二和第三个三个月期间，在分娩时以及在1岁，2岁和4岁时评估脐带血中的血铅水平（BLL）。在产后1个月评估髌骨和胫骨的骨铅水平，并在单独的模型中进行评价。为了解释累积暴露（产前、产后和累积），我们在每个阶段访视时将BLL一分为二，并确定以下内容：如果BLL至少一次高于中位数（HPb），则“较高”;如果所有BLL均低于中位数（LPb），则“较低”。我们分析了空腹血糖、HbA 1c、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（cHDL）、低密度脂蛋白胆固醇（cLDL）、体重指数、腰围（WC）、体脂百分比、收缩压（SBP）和舒张压（DBP）在6至12岁之间的两次研究访问中，并根据每个指标的临床指南创建截止点。混合效应模型用于纵向分析每个BLL评分的每个结果，调整儿童性别，胎龄大小，儿童年龄，母亲产次，母亲年龄和社会经济地位。结果如下：我们观察到在所有阶段（OR = 0.53，95%CI = 0.32-0.86）和出生后（OR = 0.59，95%CI = 0.36-0.94）的HPb暴露与TC以及产前HPb和TG（OR = 0.65，95%CI = 0.44-0.95）相关。各阶段的HPb与WC（OR = 0.27，95%CI = 0.08-0.86）、BMI（OR = 0.33，95%CI = 0.11-0.99）、SBP（OR = 0.53，95%CI = 0.32-0.85）和DBP（OR = 0.57，95%CI = 0.34-0.95）相关。髌骨铅水平与cHDL相关（OR = 1.03，95%CI = 1.00-1.07），胫骨铅水平与TG相关（OR = 0.95，95%CI = 0.91-0.99）。结论：生命早期铅暴露可能会改变代谢综合征的早期指标。对这些儿童的随访将有助于进一步确定长期接触的影响。
Background: Exposure to lead (Pb) during the early life stages has been associated with the development of metabolic syndrome (MetS). Longitudinal studies of Pb exposure in critical developmental windows in children are limited. Methods: Our study included 601 mother–child dyads from the PROGRESS (Programming Research in Obesity, Growth, Environment and Social Stressors) birth cohort. Blood lead levels (BLLs) were assessed during the second and third gestational trimesters, in cord blood at delivery, and at ages 1, 2, and 4 years. Bone lead levels in the patella and tibia were assessed at 1 month postpartum and evaluated in separate models. To account for cumulative exposure (prenatal, postnatal, and cumulative), we dichotomized the BLLs at each stage visit and determined the following: “higher” if a BLL was at least once above the median (HPb) and “lower” if all BLLs were below the median (LPb). We analyzed fasting glucose, HbA1c, triglycerides (TGs), total cholesterol (TC), high-density lipoprotein cholesterol (cHDL), low-density lipoprotein cholesterol (cLDL), body mass index, waist circumference (WC), body fat percentage, and systolic (SBP) and diastolic blood pressure (DBP) at two study visits between 6 and 12 years of age and created cutoff points based on the clinical guidelines for each indicator. Mixed effects models were used to analyze each outcome longitudinally for each BLL score, adjusting for child's sex, size for gestational age, child's age, maternal parity, mother's age, and socioeconomic status. Results: We observed associations for HPb exposure and TC in all stages (OR = 0.53, 95%CI = 0.32–0.86) and postnatally (OR = 0.59, 95%CI = 0.36–0.94) and for prenatal HPb and TGs (OR = 0.65, 95%CI = 0.44–0.95). HPb at all stages was associated with WC (OR = 0.27, 95%CI = 0.08–0.86), BMI (OR = 0.33, 95%CI = 0.11–0.99), SBP (OR = 0.53, 95%CI = 0.32–0.85), and DBP (OR = 0.57, 95%CI = 0.34–0.95). Pb levels in the patella were associated with cHDL (OR = 1.03, 95%CI = 1.00–1.07) and those in the tibia with TGs (OR = 0.95, 95%CI = 0.91–0.99). Conclusion: Early life exposure to Pb may alter early indicators of MetS. A follow-up of these children will allow for more definition on the impact of longer-term exposures.
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影响因子：
5.1
作者：
Afeiche, Myriam;Peterson, Karen E.;Tellez-Rojo, Martha M.
通讯作者：
Tellez-Rojo, Martha M.
影响因子：
1.9
作者：
Itzel Pena-Espinoza, Barbara;de los Angeles Granados-Silvestre, Maria;Menjivar, Marta
通讯作者：
Menjivar, Marta
DOI：
10.21149/10555
发表时间：
2019-12-01
期刊：
Salud Pública de México
影响因子：
--
作者：
Téllez-Rojo, Martha María;Bautista-Arredondo, Luis F;Tamayo-Ortiz, Marcela
通讯作者：
Tamayo-Ortiz, Marcela
影响因子：
6.7
作者：
Jang, Hye-Ock;Kim, Ji-Suk;Yun, Il
通讯作者：
Yun, Il
影响因子：
11.8
作者：
Farzan SF;Howe CG;Chen Y;Gilbert-Diamond D;Cottingham KL;Jackson BP;Weinstein AR;Karagas MR
通讯作者：
Karagas MR